Va pyramidal neurons | RS pyramidal neurons | IB pyramidal neurons | |
---|---|---|---|
(a) Passive intrinsic properties | |||
n | 69 | 49 | 20 |
Vrmp (mV) | -62.8 ± 4.3 | -62.6 ± 4.3 | -63.3 ± 4.4 |
Rin (MΩ) | 139.9 ± 55.7 | 127.8 ± 42.9 | 169.6 ± 71.7** |
τ (ms) | 21.6 ± 8.2 | 21.2 ± 7.4 | 22.8 ± 10.0 |
(b) Active intrinsic properties | |||
AP threshold (mV) | -41.8 ± 5.0 | -42.2 ± 4.2 | -40.7 ± 6.5 |
First AP amplitude (mV) | 68.4 ± 12.9 | 68.1 ± 13.1 | 69.1 ± 12.7 |
Second AP amplitude (mV) | 63.5 ± 12.8 | 67.3 ± 12.6 | 54.2 ± 7.4** |
First ISI (ms) | 39.4 ± 29.1 | 52.6 ± 24.4 | 7.6 ± 1.7** |
Second ISI (ms) | 70.8 ± 31.3 | 84.0 ± 23.8 | 39.2 ± 23.8* |
(c) Synaptic inputs following orthodromic electrical stimulation of afferent fibers | |||
n | 28 | 17 | 11 |
Latency EPSP (ms) | 2.5 ± 0.7 | 2.4 ± 0.5 | 2.8 ± 1.0 |
Latency fast IPSP (ms) | 13.4 ± 3.1 (23/28 cells) | 13.8 ± 3.4 (16/17 cells) | 12.4 ± 2.1 (7/11 cells) |
Latency slow IPSP (ms) | 92.8 ± 12.4 (22/28 cells) | 89.4 ± 10.9 (14/17 cells) | 98.9 ± 13.3 (8/11 cells) |
Vrev fast IPSP (mV) | -59.7 ± 3.6 | -60.4 ± 2.8 | -57.3 ± 5.4 |
Vrev slow IPSP (mV) | -78.1 ± 5.2 | -79.2 ± 4.2 | -75.3 ± 6.6 |
-
Active intrinsic properties were determined by applying suprathreshold depolarizing current pulses at Vrmp eliciting 5-10 APs. Asterisks mark significant differences between RS and IB pyramidal neurons (*P < 0.05, **P < 0.01, ***P < 0.001); data are means ± SD.