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Article: Differential slow inactivation and use-dependent inhibition of Nav1.8 channels contribute to distinct firing properties in IB4+ and IB4- DRG neurons.

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Choi JS; Dib-Hajj SD; Waxman SG
J. Neurophysiol., 2007



TABLE 1.Action potential characteristics of IB4+ and IB4– neurons
Cell Capacitance, pF Input Resistance, MΩ Resting Membrane Potential, mV 0.5-ms Step Current Injection
 400-ms Step Current Injection
 400-ms Ramp Current Injection
AP peak, mV Current threshold, nA AP duration at 0 mV, ms Voltage threshold, mV Current threshold, pA Voltage threshold, mV No. of APs at 500 pA, >0 mV No. of APs >0 mV Time to First AP Peak, ms
IB4+ 26.1 ± 1.5 491.8 ± 79.7 –59.9 ± 1.9 56.8 ± 1.1 2.3 ± 0.2 2.2 ± 0.2 –30.2 ± 1.3 226.1 ± 27.0 –30.0 ± 1.2 2.2 ± 0.6 5.1 ± 1.0 224.3 ± 32.7
IB4– 25.9 ± 1.2 667.5 ± 111.0 –48.9 ± 1.6** 58.2 ± 2.5 1.8 ± 0.1* 2.2 ± 0.2 –31.0 ± 1.9 104.8 ± 19.4** –30.1 ± 1.3 7.5 ± 1.3** 10.9 ± 1.6** 73.8 ± 14.5**
Values are means ± SE.

* P<0.05;

** P<0.001.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dorsal root ganglion cell Isolectin B(4)-positive nonpeptidergic neurons spike peak (mV) 4.0 4.0 (mV) Data Table
Dorsal root ganglion cell Isolectin B(4)-positive nonpeptidergic neurons cell capacitance (pF) 26.1 ± 1.5 26.1 (pF) Data Table
Dorsal root ganglion cell Isolectin B(4)-positive nonpeptidergic neurons input resistance (MΩ) 491.8 ± 79.7 491.8 (MΩ) Data Table
Dorsal root ganglion cell Isolectin B(4)-positive nonpeptidergic neurons resting membrane potential (mV) -59.9 ± 1.9 -59.9 (mV) Data Table
Dorsal root ganglion cell Isolectin B(4)-positive nonpeptidergic neurons rheobase (pA) 56.8 ± 1.1 56.8 (pA) Data Table
Dorsal root ganglion cell Isolectin B(4)-positive nonpeptidergic neurons spike threshold (mV) 2.3 ± 0.2 -- Data Table
Dorsal root ganglion cell Isolectin B(4)-positive nonpeptidergic neurons first spike latency (ms) 226.1 ± 27.0 226.1 (ms) Data Table
Dorsal root ganglion cell Isolectin B(4)-negative peptidergic neurons spike peak (mV) 4.0 4.0 (mV) Data Table
Dorsal root ganglion cell Isolectin B(4)-negative peptidergic neurons cell capacitance (pF) 25.9 ± 1.2 25.9 (pF) Data Table
Dorsal root ganglion cell Isolectin B(4)-negative peptidergic neurons input resistance (MΩ) 667.5 ± 111.0 667.5 (MΩ) Data Table
Dorsal root ganglion cell Isolectin B(4)-negative peptidergic neurons resting membrane potential (mV) -48.9 ± 1.6 -48.9 (mV) Data Table
Dorsal root ganglion cell Isolectin B(4)-negative peptidergic neurons rheobase (pA) 58.2 ± 2.5 58.2 (pA) Data Table
Dorsal root ganglion cell Isolectin B(4)-negative peptidergic neurons spike threshold (mV) 1.8 ± 0.1 -- Data Table
Dorsal root ganglion cell Isolectin B(4)-negative peptidergic neurons first spike latency (ms) 104.8 ± 19.4 104.8 (ms) Data Table