TABLE 2.Effect of K+ channel blockers on spontaneous activity
|
|||
Axotomy + ACSF | Axotomy + TEA | Axotomy + 4-AP | |
|
|||
Number of animals | 3 | 3 | 3 |
Incidence of Spontaneous activity, % | 21.1 ± 0.5 | 31.5 ± 1.0 | 31.8 ± 2.9 |
P value vs. ACSF | — | 0.0001 | 0.0001 |
Total number of fibers recorded | 503 | 555 | 576 |
Incidence of spontaneous activity determined on post-operative day (POD) 7 after perfusion of the injured nerve with K+ blockers TEA (10 mM) or 4-aminopyridine (4-AP; 10 mM), or with vehicle (ACSF). The pump was still in place at the time spontaneous
activity was measured. SEs are based on comparison between different animals. P values are based on Fisher's exact tests on the combined data. There was no significant difference between the TEA and 4-AP
groups.