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Article: Pre- and postnatal differences in membrane, action potential, and ion channel properties of rostral nucleus of the solitary tract neurons.

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Suwabe T; Mistretta CM; Krull C; Bradley RM
J. Neurophysiol., 2011


Table 1.

Electrophysiological properties of prenatal and early postnatal neurons in rNST

E14/16 n E18/20 n P0-2 n P6-8 n P14-20 n
Vrest (mV) −36 ± 2 19 −49 ± 2 18 −52 ± 2 23 −49 ± 2 15 −56 ± 1 36
Rinput (GΩ) 2.0 ± 0.4 19 1.9 ± 0.2 18 1.3 ± 0.2 23 1.0 ± 0.1 15 0.7 ± 0.1 36
Membrane time constant (ms) 92 ± 14 19 75 ± 6 22 70 ± 9 23 55 ± 5 19 41 ± 3 36
Cm (pF) 31 ± 1 19 37 ± 2 18 52 ± 3 23 52 ± 4 15 56 ± 3 36
AP threshold (mV) −30 ± 2 14 −34 ± 1 20 −36 ± 1 25 −38 ± 2 18 −39 ± 1 39
AP height (mV) 18 ± 2 14 34 ± 3 20 43 ± 3 25 50 ± 3 18 61 ± 2 39
AP peak potential (mV) −12 ± 2 14 −0.4 ± 3 20 7 ± 2 25 12 ± 2 18 22 ± 1 39
AP rising velocity (mV/ms) 8 ± 1 24 19 ± 2 26 34 ± 4 29 44 ± 5 19 82 ± 4 40
AP falling velocity (mV/ms) 5 ± 0.3 24 8 ± 1 26 16 ± 4 29 22 ± 2 19 45 ± 2 40
AP half-width (ms) 12 ± 1 14 6 ± 1 20 4 ± 0.3 25 3 ± 0.3 18 1.7 ± 0.1 39
AHP amplitude (mV) 5 ± 1 14 7 ± 1 20 12 ± 1 25 15 ± 1 18 15 ± 1 39
AHP peak time (ms) 20 ± 3 14 14 ± 2 20 16 ± 1 25 16 ± 2 18 6 ± 1 39
AP discharge rate (/s) 1 ± 3 35 3 ± 1 27 8 ± 1 30 11 ± 2 20 17 ± 1 39
IKA amplitude (pA) 77 ± 12 29 143 ± 18 23 182 ± 30 28 242 ± 32 14 247 ± 33 25
IKA decay time constant (ms) 23 ± 2 14 29 ± 4 17 44 ± 8 20 43 ± 12 11 99 ± 12 19
Ih amplitude (pA) 12 ± 3 14 17 ± 2 18 32 ± 5 22 36 ± 7 13 29 ± 4 27

  • Values are means ± SE. rNST, rostral nucleus of the solitary tract; E, embryonic day; P, postnatal day; Vrest, resting membrane potential; Rinput, input resistance; Cm, membrane capacitance; AP, action potential; AHP, after-hyperpolarization; IKA, transient outward potassium current; Ih, inward current.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron resting membrane potential (mV) -56.0 ± 1.0 (39) -56.0 (mV) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron spike half-width (ms) 4.0 ± 0.3 (25) 4.0 (ms) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron spike half-width (ms) 3.0 ± 0.3 (18) 3.0 (ms) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron spike half-width (ms) 1.7 ± 0.1 (39) 1.7 (ms) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron AHP amplitude (mV) 12.0 ± 1.0 (25) 12.0 (mV) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron AHP amplitude (mV) 15.0 ± 1.0 (18) 15.0 (mV) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron AHP amplitude (mV) 15.0 ± 1.0 (39) 15.0 (mV) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron AHP duration (ms) 16.0 ± 1.0 (25) 16.0 (ms) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron AHP duration (ms) 16.0 ± 2.0 (18) 16.0 (ms) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron AHP duration (ms) 6.0 ± 1.0 (39) 6.0 (ms) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron firing frequency 8.0 ± 1.0 (25) 8.0 (Hz) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron firing frequency 11.0 ± 2.0 (18) 11.0 (Hz) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron firing frequency 17.0 ± 1.0 (39) 17.0 (Hz) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron input resistance (GΩ) 1.3 ± 0.2 (25) 1300.0 (MΩ) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron input resistance (GΩ) 1.0 ± 0.1 (18) 1000.0 (MΩ) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron input resistance (GΩ) 0.7 ± 0.1 (39) 700.0 (MΩ) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron membrane time constant (ms) 70.0 ± 9.0 (25) 70.0 (ms) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron membrane time constant (ms) 55.0 ± 5.0 (18) 55.0 (ms) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron membrane time constant (ms) 41.0 ± 3.0 (39) 41.0 (ms) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron cell capacitance (pF) 52.0 ± 3.0 (25) 52.0 (pF) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron cell capacitance (pF) 52.0 ± 4.0 (18) 52.0 (pF) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron cell capacitance (pF) 56.0 ± 3.0 (39) 56.0 (pF) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron spike threshold (mV) -36.0 ± 1.0 (25) -36.0 (mV) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron spike threshold (mV) -38.0 ± 2.0 (18) -38.0 (mV) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron spike threshold (mV) -39.0 ± 1.0 (39) -39.0 (mV) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron resting membrane potential (mV) -52.0 ± 2.0 (25) -52.0 (mV) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron spike amplitude (mV) 43.0 ± 3.0 (25) 43.0 (mV) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron spike amplitude (mV) 50.0 ± 3.0 (18) 50.0 (mV) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron spike amplitude (mV) 61.0 ± 2.0 (39) 61.0 (mV) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron spike peak (mV) 7.0 ± 2.0 (25) 7.0 (mV) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron spike peak (mV) 12.0 ± 2.0 (18) 12.0 (mV) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron spike peak (mV) 22.0 ± 1.0 (39) 22.0 (mV) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron resting membrane potential (mV) -49.0 ± 2.0 (18) -49.0 (mV) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron spike max rise slope (mV/ms) 34.0 ± 4.0 (25) 34.0 (mV/ms) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron spike max rise slope (mV/ms) 44.0 ± 5.0 (18) 44.0 (mV/ms) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron spike max rise slope (mV/ms) 82.0 ± 4.0 (39) 82.0 (mV/ms) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron spike max decay slope (mV/ms) 16.0 ± 4.0 (25) 16.0 (mV/ms) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron spike max decay slope (mV/ms) 22.0 ± 2.0 (18) 22.0 (mV/ms) Data Table
Nucleus of the solitary tract principal cell rostral nucleus of the solitary tract neuron spike max decay slope (mV/ms) 45.0 ± 2.0 (39) 45.0 (mV/ms) Data Table