Article: Preventing effect of L-type calcium channel blockade on electrophysiological alterations in dentate gyrus granule cells induced by entorhinal amyloid pathology.

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Pourbadie HG; Naderi N; Mehranfard N; Janahmadi M; Khodagholi F; Motamedi F
PLoS ONE, 2015

10.1371/journal.pone.0117555.t001

Table 1 Summary of membrane properties of DG granule cells in different groups.

Parameters	Control (n = 16 of 7 rats)	EC-Aβ (n = 19 of 8 rats)	EC-Aβ+ ISR (n = 15 of 5 rats)	EC-Aβ+ NIM (n = 14 of 4 rats)
RMP (mV)	-73.38 ± 1.653	-74.43 ± 1.135	-78.31 ± 2.580	-73.25 ± 1.887
Threshold (mV)	-39.38 ± 1.139	-39.33 ± 1.162	-40.01 ± 1.397	-39.09± 0.81
Peak Amplitude (mV)	69.72 ± 1.816	72.87 ± 2.174	68.20 ± 2.564	66.74 ± 3.13
Rise slope 10-90% (mV/ms)	73.56 ± 6.306	76.65 ± 6.002	76.15 ± 8.053	72.70 ± 6.895
Decay slope 10-90% (mV/ms)	-26.00 ± 2.828	-30.40 ± 2.851	-29.60 ± 2.941	-28.91 ± 1.865
Half width (ms)	1.713 ± 0.081	1.547 ± 0.07	1.716 ± 0.043	1.788 ± 0.1

Values are mean ± SEM. One way ANOVA showed no significant difference between different groups.

Inferred neuron-electrophysiology data values

Neuron Type	Ephys Prop	Extracted Value	Standardized Value	Content Source
Dentate gyrus granule cell	spike amplitude (mV)	69.72 ± 1.816 (16)	69.72 (mV)	Data Table
Dentate gyrus granule cell	spike max rise slope (mV/ms)	73.56 ± 6.306 (16)	73.56 (mV/ms)	Data Table
Dentate gyrus granule cell	resting membrane potential (mV)	-73.38 ± 1.653 (16)	-73.38 (mV)	Data Table
Dentate gyrus granule cell	spike max decay slope (mV/ms)	-26.0 ± 2.828 (16)	26.0 (mV/ms)	Data Table
Dentate gyrus granule cell	spike half-width (ms)	1.713 ± 0.081 (16)	1.713 (ms)	Data Table
Dentate gyrus granule cell	spike threshold (mV)	-39.38 ± 1.139 (16)	-39.38 (mV)	Data Table