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Article: Anatomically heterogeneous populations of CB1 cannabinoid receptor-expressing interneurons in the CA3 region of the hippocampus show homogeneous input-output characteristics.

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Szabó GG; Papp OI; Máté Z; Szabó G; Hájos N
Hippocampus, 2014


Table 2. Electrophysiological Properties of CB1-Expressing Interneurons
BC (n = 14)MFA (n = 16)DLI (n = 26)PPA (n = 11)P values (KW ANOVA)
Rheobase (pA)175 (80-300)100 (80 - 150)150 (68-200)150 (150-200)0.257
AP threshold (mV)-36.4 (-40.2 - -33.4)-41.1 (-43.6 - -37.9)-37.6 (-40.8 - -32.4)-35.8 (-38.3 - -33.3)0.036
AHP amplitude (mV)10.75 (8.58-15.6)14.65 (8.95 - 15.53)12.4 (10.23 - 15.63)13.7 (9.4 - 15.8)0.794
AHP 25% decay21.9 (3.45-56.75)4.4 (2.4 - 20.8)16.3 (3.15 - 36.55)4.4 (2.8 - 13.2)0.177
AHP 50% decay33 (11.6-83.2)22.6 (4.7 - 42.9)26.8 (5.9 - 58.9)10.6 (6.3 - 27.8)0.391
AHP 75% decay44.9 (16.9 - 98.7)37.9 (9.2 - 61.8)36.7 (11.3 - 75.9)22.6 (13.3 - 42.2)0.321
AP half width (ms)1.2 (1 - 1.4)1 (1 - 0.12)1.2 (1.15 - 1.6)1.3 (1 - 1.6)0.039
Maximal spike frequency (Hz)40 (31 - 43)38 (28 - 45)31 (26 - 43)41.3 (30 - 53)0.323
Accommodation ratio3.7 (2.9 - 4.8)4.1 (3.4 - 4.9)3.6 (3.1 - 4.3)4.2 (3.1 - 4.9)0.501
Ratio of AP amplitude adaptation0.89 (0.82 - 0.98)0.66 (0.59 - 0.79)0.76 (0.65 - 0.84)0.69 (0.6 - 0.76)9.49*10-4
BC (n = 14)MFA (n = 13)DLI (n = 19)PPA (n = 10)P values (KW ANOVA)
Input resistance (MΩ)130 (71 - 174)182 (145 - 207)191 (150 - 217)198 (89 - 244)0.083
Membrane time constant (ms)17.8 (11.6 - 22.8)19 (16.1 - 21.8)19.3 (16.4 - 22.1)22 (15.1 - 25.8)0.382
Membrane capacitance (nF)0.132 (0.114 - 0.190)0.105 (0.088 - 0.119)0.109 (0.096 - 0.131)0.109 (0.105 - 0.177)0.036
Relative sag amplitude0.43 (0.27 - 0.81)0.23 (0.19 - 0.42)0.19 (0.04 - 0.30)0.44 (0.31 - 0.90)0.004
Delay of sag minimum95.8 (56.9 - 119.1)106.4 (96 - 128.6)137.7 (96.7 - 200.4)107.9 (83 - 157.6)0.049

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Hippocampus CA3 dendritic layer-innervating CB1-expressing interneurons spike threshold (mV) -37.6 (26) -37.6 (mV) Data Table
Other Hippocampus CA3 perforant-path associated CB1-expressing interneurons spike threshold (mV) -35.8 (11) -35.8 (mV) Data Table
Hippocampus CA3 basket cell Hippocampus CA3 basket CB1-expressing cell AHP amplitude (mV) 10.75 (14) 10.75 (mV) Data Table
Other Hippocampus CA3 mossy fiber associated CB1-expressing interneurons AHP amplitude (mV) 14.65 (16) 14.65 (mV) Data Table
Other Hippocampus CA3 dendritic layer-innervating CB1-expressing interneurons AHP amplitude (mV) 12.4 (26) 12.4 (mV) Data Table
Other Hippocampus CA3 perforant-path associated CB1-expressing interneurons AHP amplitude (mV) 13.7 (11) 13.7 (mV) Data Table
Hippocampus CA3 basket cell Hippocampus CA3 basket CB1-expressing cell rheobase (pA) 175.0 (14) 175.0 (pA) Data Table
Other Hippocampus CA3 mossy fiber associated CB1-expressing interneurons rheobase (pA) 100.0 (16) 100.0 (pA) Data Table
Hippocampus CA3 basket cell Hippocampus CA3 basket CB1-expressing cell spike half-width (ms) 1.2 (14) 1.2 (ms) Data Table
Other Hippocampus CA3 mossy fiber associated CB1-expressing interneurons spike half-width (ms) 1.0 (16) 1.0 (ms) Data Table
Other Hippocampus CA3 dendritic layer-innervating CB1-expressing interneurons rheobase (pA) 150.0 (26) 150.0 (pA) Data Table
Other Hippocampus CA3 dendritic layer-innervating CB1-expressing interneurons spike half-width (ms) 1.2 (26) 1.2 (ms) Data Table
Other Hippocampus CA3 perforant-path associated CB1-expressing interneurons spike half-width (ms) 1.3 (11) 1.3 (ms) Data Table
Hippocampus CA3 basket cell Hippocampus CA3 basket CB1-expressing cell maximum firing rate (Hz) 40.0 (14) 40.0 (Hz) Data Table
Other Hippocampus CA3 mossy fiber associated CB1-expressing interneurons maximum firing rate (Hz) 38.0 (16) 38.0 (Hz) Data Table
Other Hippocampus CA3 dendritic layer-innervating CB1-expressing interneurons maximum firing rate (Hz) 31.0 (26) 31.0 (Hz) Data Table
Other Hippocampus CA3 perforant-path associated CB1-expressing interneurons maximum firing rate (Hz) 41.3 (11) 41.3 (Hz) Data Table
Other Hippocampus CA3 perforant-path associated CB1-expressing interneurons rheobase (pA) 150.0 (11) 150.0 (pA) Data Table
Hippocampus CA3 basket cell Hippocampus CA3 basket CB1-expressing cell adaptation ratio (last/first ISI) 3.7 (14) 3.7 (ratio) Data Table
Other Hippocampus CA3 mossy fiber associated CB1-expressing interneurons adaptation ratio (last/first ISI) 4.1 (16) 4.1 (ratio) Data Table
Other Hippocampus CA3 dendritic layer-innervating CB1-expressing interneurons adaptation ratio (last/first ISI) 3.6 (26) 3.6 (ratio) Data Table
Other Hippocampus CA3 perforant-path associated CB1-expressing interneurons adaptation ratio (last/first ISI) 4.2 (11) 4.2 (ratio) Data Table
Hippocampus CA3 basket cell Hippocampus CA3 basket CB1-expressing cell input resistance (MΩ) 130.0 (14) 130.0 (MΩ) Data Table
Other Hippocampus CA3 mossy fiber associated CB1-expressing interneurons input resistance (MΩ) 182.0 (16) 182.0 (MΩ) Data Table
Other Hippocampus CA3 dendritic layer-innervating CB1-expressing interneurons input resistance (MΩ) 191.0 (26) 191.0 (MΩ) Data Table
Other Hippocampus CA3 perforant-path associated CB1-expressing interneurons input resistance (MΩ) 198.0 (11) 198.0 (MΩ) Data Table
Hippocampus CA3 basket cell Hippocampus CA3 basket CB1-expressing cell membrane time constant (ms) 17.8 (14) 17.8 (ms) Data Table
Other Hippocampus CA3 mossy fiber associated CB1-expressing interneurons membrane time constant (ms) 19.0 (16) 19.0 (ms) Data Table
Other Hippocampus CA3 dendritic layer-innervating CB1-expressing interneurons membrane time constant (ms) 19.3 (26) 19.3 (ms) Data Table
Other Hippocampus CA3 perforant-path associated CB1-expressing interneurons membrane time constant (ms) 22.0 (11) 22.0 (ms) Data Table
Hippocampus CA3 basket cell Hippocampus CA3 basket CB1-expressing cell spike threshold (mV) -36.4 (14) -36.4 (mV) Data Table
Hippocampus CA3 basket cell Hippocampus CA3 basket CB1-expressing cell cell capacitance (nF) 0.132 (14) 132.0 (pF) Data Table
Other Hippocampus CA3 mossy fiber associated CB1-expressing interneurons cell capacitance (nF) 0.105 (16) 105.0 (pF) Data Table
Other Hippocampus CA3 dendritic layer-innervating CB1-expressing interneurons cell capacitance (nF) 0.109 (26) 109.0 (pF) Data Table
Other Hippocampus CA3 perforant-path associated CB1-expressing interneurons cell capacitance (nF) 0.109 (11) 109.0 (pF) Data Table
Hippocampus CA3 basket cell Hippocampus CA3 basket CB1-expressing cell sag amplitude 0.43 (14) 0.43 (mV) Data Table
Other Hippocampus CA3 mossy fiber associated CB1-expressing interneurons sag amplitude 0.23 (16) 0.23 (mV) Data Table
Other Hippocampus CA3 dendritic layer-innervating CB1-expressing interneurons sag amplitude 0.19 (26) 0.19 (mV) Data Table
Other Hippocampus CA3 perforant-path associated CB1-expressing interneurons sag amplitude 0.44 (11) 0.44 (mV) Data Table
Other Hippocampus CA3 mossy fiber associated CB1-expressing interneurons spike threshold (mV) -41.1 (16) -41.1 (mV) Data Table