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Article: Shaker-related potassium channels in the central medial nucleus of the thalamus are important molecular targets for arousal suppression by volatile general anesthetics.

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Lioudyno MI; Birch AM; Tanaka BS; Sokolov Y; Goldin AL; Chandy KG; Hall JE; Alkire MT
J. Neurosci., 2013


Table 2.

The effect of 350 pm ShK-186 on action potential firing properties of CMT neurons and the lack of sevoflurane's effect in the presence of ShK-186

Resting potential (mV) AP threshold (mV) Peak amplitude (mV) Half-width (ms) ΔVt Input resistance (MΩ) n
Control -60.1 ± 0.9 -39.6 ± 1.2 26.9 ± 4.2 0.58 ± 0.05 0.39 ± 0.1 223 ± 24 5
350 pm ShK-186 -54.7 ± 2.0* -40 ± 1.2 24.4 ± 4 0.59 ± 0.06 0.49 ± 0.1 234 ± 41 5
0.2 mm sevoflurane plus 350 pm ShK-186 -53.8 ± 2.4 -36.5 ± 2 23.8 ± 3.9 0.6 ± 0.04 0.57 ± 0.1 259 ± 37 5
  • The series of tonic action potentials was induced by injection of 40 pA current. The data are presented as mean ± SEM.

  • *p < 0.05 (vs control, paired t test).


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