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Article: Development of GABA circuitry of fast-spiking basket interneurons in the medial prefrontal cortex of erbb4-mutant mice.

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Yang JM; Zhang J; Chen XJ; Geng HY; Ye M; Spitzer NC; Luo JH; Duan SM; Li XM
J. Neurosci., 2013


Table 1.

Intrinsic properties of FS basket cells and PNs in control and KO adult (P60-P90) mice

FS basket cells PNs
Control (n = 8) KO (n = 8) Control (n = 8) KO (n = 8)
Cm (pF) 56.35 ± 2.83 59.66 ± 3.23 178.42 ± 8.38 186.99 ± 9.34
RMP (mV) -64.44 ± 1.67 -64.89 ± 0.94 -68.71 ± 0.71 -69.06 ± 0.68
τm (ms) 4.16 ± 0.16 3.91 ± 0.25 13.63 ± 0.66 14.53 ± 1.06
Rin (MΩ) 82.67 ± 4.69 63.68 ± 3.82* 78.42 ± 4.12 80.75 ± 4.48
AP threshold (mV) -40.63 ± 0.52 -40.32 ± 0.43 -43.16 ± 0.57 -43.88 ± 0.81
AP amplitude (mV) 59.73 ± 2.35 57.35 ± 1.58 85.45 ± 1.69 86.21 ± 1.60
AP duration (ms) 0.23 ± 0.01 0.23 ± 0.01 0.62 ± 0.01 0.63 ± 0.01
AHP amplitude (mV) 19.25 ± 0.95 18.68 ± 0.73 9.45 ± 0.56 10.07 ± 0.48
Soma size (μm2) 269.34 ± 13.41 279.35 ± 13.25 N/A N/A
RI (pA) 383.84 ± 25.49 520.64 ± 29.86 282.14 ± 15.32 292.50 ± 19.21

  • Mean ± SEM;

  • ↵*p < 0.05 compared with control. Cm, Membrane capacitance; RMP, resting membrane potential; τm, membrane time constant; Rin, membrane input resistance; AP, action potential; AHP, afterhyperpolarization; RI, Rheo-base current; N/A, no answer.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex basket cell medial frontal cortex basket fast-spiking parvalbumin positive EGFP-expressing GABAergic cell membrane time constant (ms) 4.16 ± 0.16 (8) 4.16 (ms) Data Table
Neocortex pyramidal cell layer 5-6 medial frontal cortex layer 5-6 pyramidal cell membrane time constant (ms) 13.63 ± 0.66 (8) 13.63 (ms) Data Table
Neocortex basket cell medial frontal cortex basket fast-spiking parvalbumin positive EGFP-expressing GABAergic cell input resistance (MΩ) 82.67 ± 4.69 (8) 82.67 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 medial frontal cortex layer 5-6 pyramidal cell input resistance (MΩ) 78.42 ± 4.12 (8) 78.42 (MΩ) Data Table
Neocortex basket cell medial frontal cortex basket fast-spiking parvalbumin positive EGFP-expressing GABAergic cell cell capacitance (pF) 56.35 ± 2.83 (8) 56.35 (pF) Data Table
Neocortex basket cell medial frontal cortex basket fast-spiking parvalbumin positive EGFP-expressing GABAergic cell spike threshold (mV) -40.63 ± 0.52 (8) -40.63 (mV) Data Table
Neocortex pyramidal cell layer 5-6 medial frontal cortex layer 5-6 pyramidal cell spike threshold (mV) -43.16 ± 0.57 (8) -43.16 (mV) Data Table
Neocortex basket cell medial frontal cortex basket fast-spiking parvalbumin positive EGFP-expressing GABAergic cell spike amplitude (mV) 59.73 ± 2.35 (8) 59.73 (mV) Data Table
Neocortex pyramidal cell layer 5-6 medial frontal cortex layer 5-6 pyramidal cell spike amplitude (mV) 85.45 ± 1.69 (8) 85.45 (mV) Data Table
Neocortex basket cell medial frontal cortex basket fast-spiking parvalbumin positive EGFP-expressing GABAergic cell spike half-width (ms) 0.23 ± 0.01 (8) 0.23 (ms) Data Table
Neocortex pyramidal cell layer 5-6 medial frontal cortex layer 5-6 pyramidal cell spike half-width (ms) 0.62 ± 0.01 (8) 0.62 (ms) Data Table
Neocortex basket cell medial frontal cortex basket fast-spiking parvalbumin positive EGFP-expressing GABAergic cell AHP amplitude (mV) 19.25 ± 0.95 (8) 19.25 (mV) Data Table
Neocortex pyramidal cell layer 5-6 medial frontal cortex layer 5-6 pyramidal cell AHP amplitude (mV) 9.45 ± 0.56 (8) 9.45 (mV) Data Table
Neocortex pyramidal cell layer 5-6 medial frontal cortex layer 5-6 pyramidal cell cell capacitance (pF) 178.42 ± 8.38 (8) 178.42 (pF) Data Table
Neocortex basket cell medial frontal cortex basket fast-spiking parvalbumin positive EGFP-expressing GABAergic cell cell surface area 269.34 ± 13.41 (8) 269.34 (m) Data Table
Neocortex basket cell medial frontal cortex basket fast-spiking parvalbumin positive EGFP-expressing GABAergic cell rheobase (pA) 383.84 ± 25.49 (8) 383.84 (pA) Data Table
Neocortex pyramidal cell layer 5-6 medial frontal cortex layer 5-6 pyramidal cell rheobase (pA) 282.14 ± 15.32 (8) 282.14 (pA) Data Table
Neocortex basket cell medial frontal cortex basket fast-spiking parvalbumin positive EGFP-expressing GABAergic cell resting membrane potential (mV) -64.44 ± 1.67 (8) -64.44 (mV) Data Table
Neocortex pyramidal cell layer 5-6 medial frontal cortex layer 5-6 pyramidal cell resting membrane potential (mV) -68.71 ± 0.71 (8) -68.71 (mV) Data Table