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Article: NMDA receptor-dependent synaptic activation of TRPC channels in olfactory bulb granule cells.

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Stroh O; Freichel M; Kretz O; Birnbaumer L; Hartmann J; Egger V
J. Neurosci., 2012


Table 1.

Excitability and morphology of TRPC1/4 DKO granule cells versus WT granule cells

Parameter WT TRPC1/4 DKO p (Mann-Whitney test)
Mean value ± SD n Mean value ± SD n
Input resistance 1.07 ± 0.39 GΩ 20 0.89 ± 0.44 GΩ 19 0.14
sAP
    Na+ spike amplitude 105 ± 10 mV 35 111 ± 16 mV 20 0.08
    Na+ spike half-width 1.9 ± 0.4 ms 18 2.1 ± 0.4 ms 19 0.11
    Number of APs at 50 pA, 800 ms 8.8 ± 3.7 30 7.7 ± 3.8 14 0.24
Synaptic input
    Extracellular stimulation threshold 620 ± 420 μA 35 620 ± 380 μA 23 0.33
    Just subthreshold EPSP τ1/2 88 ± 58 ms 39 71 ± 54 ms 21 0.40
Morphology of apical dendrite 25 9
    Length 240 ± 150 μm 215 ± 110 μm 0.67
    Number of branchpoints 2.6 ± 1.1 2.0 ± 1.7 0.24

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