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Article: Brain activity mapping in Mecp2 mutant mice reveals functional deficits in forebrain circuits, including key nodes in the default mode network, that are reversed with ketamine treatment.

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Kron M; Howell CJ; Adams IT; Ransbottom M; Christian D; Ogier M; Katz DM
J. Neurosci., 2012


Table 6.

Quantification of Fos expression in selected brain regions of female Wt vs Het mice

Forebrain Female Wt (n = 11) Female Het (n = 9)
Piriform cortex 41.4 ± 3.7 31.8 ± 5.6#
Nucleus accumbens 48.8 ± 3.4 25.5 ± 5.6**
Cingulate cortex 28.3 ± 6.6 26.1 ± 5.7
Retrosplenial cortex 7.4 ± 1.9 1.4 ± 0.3*
Prelimbic cortex 28.5 ± 6.3 10.3 ± 2.9*
Infralimbic cortex 21.8 ± 5.5 10.8 ± 2.3#
  • Data are displayed as mean ± SEM (*p < 0.05; **p < 0.01;

  • #p < 0.15).


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Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source