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Article: COX-2-Derived Prostaglandin E2 Produced by Pyramidal Neurons Contributes to Neurovascular Coupling in the Rodent Cerebral Cortex.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Lacroix A; Toussay X; Anenberg E; Lecrux C; Ferreirós N; Karagiannis A; Plaisier F; Chausson P; Jarlier F; Burgess SA; Hillman EM; Tegeder I; Murphy TH; Hamel E; Cauli B
J. Neurosci., 2015


Table 8.

Action potential waveform properties of different neuronal populations

Pyramidal cells (n = 24) Interneurons (n = 66)
1st spike amplitude, mV 96.6 ± 2.3 89.2 ± 1.4
U(24,66) = 476,5 p = 0.00354
Int << Pyr
2nd spike amplitude, mV 95.0 ± 2.3 85.2 ± 1.5
U(24,66) = 369 p = 0.00007
Int <<< Pyr
1st spike duration, ms 1.3 ± 0.1 0.7 ± 0.1
U(24,66) = 231 p = 4.10-8
Int <<< Pyr
2nd spike duration, ms 1.3 ± 0.1 0.7 ± 0.0
U(24,66) = 223 p = 3.10-8
Int <<< Pyr
Amplitude reduction, % 1.6 ± 0.3 4.4 ± 0.8
U(24,66) = 553 p = 0.02888
Pyr < Int
Duration increase, % 0.7 ± 0.3 0.8 ± 1.9
U(24,66) = 628 p = 0.13646
n.s.
1st spike, 1st component AHP, mV -5.9 ± 0.6 -15.2 ± 0.6
U(24,66) = 52 p = 8.10-16
Int <<< Pyr
1st spike, 1st AHP component latency, ms 7.0 ± 0.6 3.8 ± 0.2
U(24,66) = 240 p = 8.10-8
Int <<< Pyr
1st spike, 2nd component AHP, mV -12.9 ± 0.6 -7.6 ± 0.9
U(24,66) = 443 p = 0.00121
Pyr << Int
1st spike, 2nd AHP component latency, ms 50.2 ± 4.5 15.6 ± 2.1
U(24,66) = 155 p = 1.10-10
Int <<< Pyr
1st spike, ADP, mV 0.0 ± 0.0 1.9 ± 0.3
U(24,66) = 444 p = 0.00125
Pyr << Int
1st spike, ADP latency, ms 0.0 ± 0.0 4.4 ± 0.7
U(24,66) = 444 p = 0.00125
Pyr << Int
2nd spike, 1st component AHP, mV -6.5 ± 0.7 -15.6 ± 0.6
U(24,66) = 82 p = 6.10-14
Int <<< Pyr
2nd spike, 1st AHP component latency, ms 9.3 ± 1.6 3.8 ± 0.3
U(24,66) = 199 p = 5.10-9
Int <<< Pyr
2nd spike, 2nd component AHP, mV -13.5 ± 0.8 -9.5 ± 0.9
U(24,66) = 494 p = 0.00608
Int << Pyr
2nd spike, 2nd AHP component latency, ms 55.6 ± 5.9 18.0 ± 1.9
U(24,66) = 172 p = 6.10-10
Int <<< Pyr
2nd spike, ADP, mV 0.0 ± 0.0 1.9 ± 0.3
U(24,66) = 432 p = 0.00082
Pyr <<< Int
2nd spike, ADP latency, ms 0.0 ± 0.0 2.9 ± 0.4
U(24,66) = 432 p = 0.00082
Pyr <<< Int

  • Pyr, Pyramidal cells; Int, interneurons; n, number of cells; Mann-Whitney U tests and corresponding exact p values; <, << and <<< indicate significantly smaller with p < 0.05, < 0.01, and <0.001, respectively; n.s., not statistically significant.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 2-3 barrel cortex layer 2-3 pyramidal cell spike amplitude (mV) 96.6 ± 2.3 (24) 96.6 (mV) Data Table
Neocortex interneuron deep barrel cortex GABAergic interneuron spike amplitude (mV) 89.2 ± 1.4 (66) 89.2 (mV) Data Table
Neocortex pyramidal cell layer 2-3 barrel cortex layer 2-3 pyramidal cell spike width (ms) 1.3 ± 0.1 (24) 1.3 (ms) Data Table
Neocortex interneuron deep barrel cortex GABAergic interneuron spike width (ms) 0.7 ± 0.1 (66) 0.7 (ms) Data Table
Neocortex pyramidal cell layer 2-3 barrel cortex layer 2-3 pyramidal cell AHP amplitude -5.9 ± 0.6 (24) 5.9 (mV) Data Table
Neocortex interneuron deep barrel cortex GABAergic interneuron AHP amplitude -15.2 ± 0.6 (66) 15.2 (mV) Data Table
Neocortex pyramidal cell layer 2-3 barrel cortex layer 2-3 pyramidal cell AHP duration 7.0 ± 0.6 (24) 7.0 (ms) Data Table
Neocortex interneuron deep barrel cortex GABAergic interneuron AHP duration 3.8 ± 0.2 (66) 3.8 (ms) Data Table
Neocortex interneuron deep barrel cortex GABAergic interneuron ADP amplitude 1.9 ± 0.3 (66) 1.9 (mV) Data Table
Neocortex pyramidal cell layer 2-3 barrel cortex layer 2-3 pyramidal cell ADP amplitude 24.0 (24) 24.0 (mV) Data Table
Neocortex interneuron deep barrel cortex GABAergic interneuron ADP duration 4.4 ± 0.7 (66) 4.4 (ms) Data Table
Neocortex pyramidal cell layer 2-3 barrel cortex layer 2-3 pyramidal cell ADP duration 24.0 (24) 24.0 (ms) Data Table