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Article: A seizure-induced gain-of-function in BK channels is associated with elevated firing activity in neocortical pyramidal neurons.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Shruti S; Clem RL; Barth AL
Neurobiol. Dis., 2008


Control24 h post-seizurep value
Resting potential (mV)- 71.18 ± 3.51 (n = 20)- 69.29 ± 0.68 (n = 26)0.07470
Input resistance (MΩ)378.84 ± 79.87 (n = 20)395.40 ± 20.19 (n = 26)0.55536
Rheobase (pA)117.10 ± 41.28 (n = 19)108.58 ± 6.17 (n = 26)0.43562
AP threshold (mV)- 27.59 ± 0.86 (n = 17)- 28.62 ± 0.70 (n = 25)0.35815
AP waveform:
Height (mV)74.71 ± 1.00 (n = 26)76.89 ± 1.10 (n = 25)0.14875
Half-width (ms)2.93 ± 0.07 (n = 26)2.44 ± 0.06 (n = 25)0.00003
Rise time (ms)1.52 ± 0.04 (n = 26)1.50 ± 0.03 (n = 25)0.69828
Decay time (ms)3.00 ± 0.10 (n = 26)2.46 ± 0.06 (n = 25)0.00002
Area (mV * ms)204.22 ± 4.97 (n = 26)177.42 ± 2.81 (n = 25)< 0.00001

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 2-3 Primary Somatosensory Barrel Cortex Layer 2/3 Pyramidal Neuron rheobase (pA) 117.1 ± 41.28 117.1 (pA) Data Table
Neocortex pyramidal cell layer 2-3 Primary Somatosensory Barrel Cortex Layer 2/3 Pyramidal Neuron spike threshold (mV) -27.59 ± 0.86 -27.59 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Primary Somatosensory Barrel Cortex Layer 2/3 Pyramidal Neuron spike amplitude (mV) 74.71 ± 1.0 74.71 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Primary Somatosensory Barrel Cortex Layer 2/3 Pyramidal Neuron resting membrane potential (mV) -71.18 ± 3.51 -71.18 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Primary Somatosensory Barrel Cortex Layer 2/3 Pyramidal Neuron spike half-width (ms) 2.93 ± 0.07 2.93 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Primary Somatosensory Barrel Cortex Layer 2/3 Pyramidal Neuron spike rise time (ms) 1.52 ± 0.04 1.52 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Primary Somatosensory Barrel Cortex Layer 2/3 Pyramidal Neuron spike decay time (ms) 3.0 ± 0.1 3.0 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Primary Somatosensory Barrel Cortex Layer 2/3 Pyramidal Neuron input resistance (MΩ) 378.84 ± 79.87 378.84 (MΩ) Data Table