Article: Dendritic morphology, synaptic transmission, and activity of mature granule cells born following pilocarpine-induced status epilepticus in the rat.
A comparison of intrinsic membrane and firing properties of newborn granule cells in the control and SE groups.
Parameters
Control
SE
P-value
% of cells with spontaneous firing
11.8 (2/17)
17.6 (3/17)
>0.10*
Resting membrane potential (mV)
-76.0±1.1
-75.8±0.9
0.8476
Input resistance (MΩ)
211.6 ± 16.6
225.4 ± 20.6
0.6050
Membrane capacitance (mF)
35.1 ± 3.2
30.8 ± 4.2
0.4240
Membrane time constant
6.89 ± 0.5
6.0 ± 0.6
0.2521
Threshold potential (mV)
-48.0±2.4
-49.0±1.4
0.7362
Amplitude of AP (mV)
77.7 ± 6.6
83.1 ± 1.8
0.4154
Width of AP (ms)
1.6 ± 0.2
1.5 ± 0.1
0.7413
ADP (mV)
4.6 ± 1.6
4.7 ± 0.5
0.8976
Area of ADP (mV.ms)
93.3 ± 26.3
120.1 ± 19.7
0.4393
Spontaneous firing, resting membrane potential, input resistance, membrane capacitance, membrane time constant are collected from 17 cells each in the control and SE groups. Parameters of action potential (AP) including the threshold potential, amplitude, width, after depolarization (ADP) and area of (ADP) calculated for 6 cells each in the control and SE groups. Data are expressed as mean ± SEM and compared with unpaired t-test except the percentages of cells with spontaneous firing and burst firing.
The percentage of cells with spontaneous firing was compared by the chi-square test.
