Article: Dopamine Modulates Spike Timing-Dependent Plasticity and Action Potential Properties in CA1 Pyramidal Neurons of Acute Rat Hippocampal Slices.

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Edelmann E; Lessmann V
Front Synaptic Neurosci, 2011

Table 3

Comparison of experimental conditions for hippocampal STDP between our own study and previously published experiments.

Study	Type of hippocampal preparation	Preparation condition	Species	Age	STDP protocol; pre: post (current injection); repeat numbers with frequency or duration	Special conditions	t-LTP
Current study	Acute slice	ACSF	Rat	15–20 days	1:1 (2–3 ms, 1 nA); 100× at 0.5 Hz	100 μM PiTX	Yes
	Acute slice	Sucrose-based ACSF (sodium-free)	Rat	15–20 days	1:1 (2–3 ms, 1 nA); 100× at 0.5 Hz	100 μM PiTX	No
					1:2 (each AP: 2 ms, 1 nA); 50× at 0.5 Hz or 70× at 5 Hz
					5:5 (each AP: 2 ms, 1 nA); 15–30× at 0.2 Hz
Debanne et al. (1994)	Slice culture	Roller-tube culture	Rat	2–4 weeks (DIV)	1:>1 (240 ms, 0.5–2.0 nA); 50–100× at ∼0.3 Hz		Yes*
Debanne et al. (1996)	Slice culture	Roller-tube culture	Rat	DIV > 14	1:6–12 (240 ms, 0.5–2.5 nA); 50–100× at 0.3 Hz	Paired recordings	Yes*
Magee and Johnston (1997)	Acute slice	ACSF/sucrose?	Rat	5–10 weeks	5 × 5:5 × 1–3 (2 ms, 2 nA at 5 Hz); 2× at ∼0.07 Hz	0.01 mM bic	Yes
Bi and Poo (1998)	Cell culture		Rat	DIV 8–14	Pre: 1 (1 ms, -70 to +30 mV); 60× at 1 Hz (post: supratheshold EPSP response)	Paired recordings	Yes
Pike et al. (1999)	Acute slice	ACSF	Rat	Young adult 120–200 g	1:1 (5 ms, 1 nA); 10× at 5 Hz	10 μM bic	No
					3:>1 (20 ms, 1 nA); 10× at 5 Hz		Yes
Gerkin et al. (2007)	Cell culture		Rat	DIV 10–15	1 (1–2 ms, 100 mV):1 (1–2 nA, 2 ms); 60× at 1 Hz	Paired recordings	Yes
Nishiyama et al. (2000)	Acute slice	ACSF	Rat	26–33 days	>1 (5 Hz):>1 (2 ms, 2 nA at 5 Hz); 16 s		Yes
			Mouse	20–23 days
Meredith et al. (2003)	Acute slice	ACSF/sucrose?	Rat	9–45 days	1:1 (5 ms, 0.1–0.85 nA); 30× at 0.2 Hz	9–15 days	Yes
			Mouse		1:1 (5 ms, 0.1–0.85 nA); 30× at 0.2 Hz	22–43 days	No
					1:1 (5 ms, 0.1–0.85 nA); 30× at 0.2 Hz + 5 μM bic	30–45 days	Yes
					1:>1 (20 ms; 0.1–0.85 nA); 30× at 0.2 Hz	22–43 days	Yes
Wittenberg and Wang (2006)	Acute slice	ACSF	Rat	14–21 days	1:1 (3 ms, 1.2–2 nA); 70–200× at 0.1–5 Hz	100 μM PiTX	No
					1:2 (20–30 ms or 2 ms × 3 ms, 1.2–2 nA); 70–100× at 5 Hz		Yes
Remy and Spruston (2007)	Acute slice	ASCF	Rat	3–5 weeks	Pre: 5 (100 Hz) inducing dendritic spikelets	4 μM SR95531 +1μM GCP52432+	Yes*
					Pre: 5 (100 Hz) without inducing dendritic spikelets	1 μM GCP52432	No
Harvey and Svoboda (2007)	Acute slice	Choline chloride	Mouse	14–18 days	1 uncaging stimulus: 3 (2 ms, 1–3 nA, 50 Hz); 60× at 2 Hz		Yes
	Organotypic slice culture	Stoppini	Rat	DIV, 7–11
Campanac and Debanne (2008)	Acute slice	Sucrose-based ACSF (sodium-free)	Rat	15–20 days	1:1 (3–5 ms, 300–500 pA); 100× at 0.33 Hz	100 μM PiTX	Yes
Carlisle et al. (2008)	Acute slice	ACSF	Mouse	6–12 months	1:1 (5–7 ms, 0.5–1 nA); 100× at 5 Hz	100 μM PiTX	No
				6–12 weeks	1:3–4 (50 ms, 0.5–1 nA); 100× at 5 Hz		Yes
Tanaka et al. (2008)	Organotypic slice culture	Stoppini	Rat	DIV 8–12	MNI-glutamate uncaging (80 s at 1 Hz):1 (2 ms, 1–2 nA)		Yes
Hardie and Spruston (2009)	Acute slice	ACSF	Rat	4–8 weeks	1:1–3 (5 ms, 1.5–3 nA); 40× at 5 Hz	4 μM SR95531+	Yes
					Weak input: synaptically driven action potentials (1–3)	1 μM GCP52432	Yes

The table compares preparation type, condition, species, age, and STDP protocol as well as the respective results in terms of induction of t-LTP. For interpretation of STDP protocol: 1:1 (2–3 ms, 1 nA); 100× at 0.5 Hz denotes one presynaptic stimulation (by extracellular stimulation, exceptions indicated) paired with one postsynaptic stimulation (induced by a 2 ms to 3 ms long 1 nA somatic current injection) repeated 100× at 0.5 Hz. *Studies do not use the definition STDP or t-LTP; PiTX, picrotoxtin; bic, bicuculline; >1, burst stimulation.

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Inferred neuron-electrophysiology data values

Neuron Type	Neuron Description	Ephys Prop	Extracted Value	Standardized Value	Content Source