AboutNeuron TypesElectrophysiology PropertiesArticlesFAQsData/APIGet Involved

Article: Slowly inactivating component of Na+ current in peri-somatic region of hippocampal CA1 pyramidal neurons.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Park YY; Johnston D; Gray R
J. Neurophysiol., 2013


Table 1.

Effect of Na+ channel blockers on INaS and INaT

INaS, ActivationINaT, ActivationINaT, Inactivation
nGNaS, max change, %ΔV1/2, mVΔknGNaT, max change, %ΔV1/2, mVΔknINaT, max change, %ΔV1/2, mVΔk
Hexanol18-71.1 ± 3.2-3.01 ± 0.70-0.45 ± 0.355-35.3 ± 8.0*2.05 ± 1.010.19 ± 0.144-23.3 ± 4.1*-6.10 ± 1.03-0.16 ± 0.33
Riluzole7-73.9 ± 3.4-4.48 ± 1.480.28 ± 0.835-32.8 ± 6.4*1.89 ± 0.730.41 ± 0.464-27.1 ± 3.3-13.1 ± 1.41*-0.90 ± 0.22
Ranolazine12-34.9 ± 5.00.55 ± 0.700.88 ± 0.227-25.0 ± 1.51.84 ± 0.480.10 ± 0.257-14.2 ± 1.6-3.34 ± 0.47-0.52 ± 0.20
Saline11-21.4 ± 4.6-1.54 ± 0.60-0.10 ± 0.305-10.4 ± 2.3-0.55 ± 0.650.07 ± 0.495-2.20 ± 3.1-3.84 ± 0.34-0.62 ± 0.53
  • Values are means ± SE. The effect of each drug was compared with the saline condition. Maximum conductance Gmax (or current amplitude Imax) change was calculated by (Gmax,Drug - Gmax,Baseline)/Gmax,Baseline × 100; ΔV1/2 (or Δk) was calculated by V1/2, Drug - V1/2, Baseline (or kDrug - kBaseline). Kruskal-Wallis test and post hoc Dunn's test:

  • * P < 0.05;

  • P < 0.01;

  • P < 0.001.


Report miscurated data

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source