Article: Electrophysiological properties of genetically identified subtypes of layer 5 neocortical pyramidal neurons: Ca²⁺ dependence and differential modulation by norepinephrine.

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Guan D; Armstrong WE; Foehring RC
J. Neurophysiol., 2015

Table 4.

Repetitive firing: slopes of the relationship between average firing frequency vs. current (f-I) and SFA

	f-I Slope, 200 ms, Hz/nA	f-I Slope, 2 s, Hz/nA	% Adaptation	Adaptation Index
Etv1	79 ± 1 (21)	30 ± 1 (22)^†^‡	76 ± 2 (21)^‡	39 ± 7 (21)
Glt	89 ± 1 (30)	72 ± 1 (30)^*	17 ± 2 (27)^*^‡	1.1 ± 0.3 (27)^*
Layer 2/3	92 ± 10 (15)	55 ± 7 (15)^†	52 ± 4 (15)	24 ± 14 (15)

Data are presented as means ± SE (n, number of cells). Firing was elicited in response to 2-s current injections at different amplitudes. Percentage of adaptation (% Adaptation) = 100 × (frequency of 3rd ISI) - (frequency of final ISI)/(frequency of 3rd ISI). Adaptation index = 100 × the slope of a linear regression line fit to 1/ISI vs. ISI number (Groh et al. 2010). Percent adaptation and adaptation index were for firing at 300 pA.
↵* Significant difference, glt from etv1 (P < 0.05, t-test).
↵† Significant difference from same cell type (etv1 or glt) vs. 200 ms f-I slope (P < 0.05, t-test).
↵‡ Significant difference vs. layer 2/3 (ANOVA with Tukey's post hoc test). SFA, spike frequency adaptation; ISI, interspike interval.

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Inferred neuron-electrophysiology data values

Neuron Type	Neuron Description	Ephys Prop	Extracted Value	Standardized Value	Content Source
Neocortex pyramidal cell layer 5-6	somatosensory cortex layer 5a corticostriatal Etv1-expressing slender-tufted pyramidal neurons	FI slope (2 s)	30.0 ± 1.0 (22)	--	Data Table
Neocortex pyramidal cell layer 5-6	somatosensory cortex layer 5a corticostriatal Etv1-expressing slender-tufted pyramidal neurons	adaptation percent (1 – first/last ISI)	76.0 ± 2.0 (21)	76.0 (ratio)	Data Table
Neocortex pyramidal cell layer 5-6	somatosensory cortex layer 5a corticostriatal Etv1-expressing slender-tufted pyramidal neurons	adaptation ratio (other)	39.0 ± 7.0 (21)	39.0 (None)	Data Table
Neocortex pyramidal cell layer 5-6	Somatosensory cortex layer 5b Glt25d2-expressing thick-tufted pyramidal neurons	FI slope (2 s)	72.0 ± 1.0 (30)	--	Data Table
Neocortex pyramidal cell layer 5-6	Somatosensory cortex layer 5b Glt25d2-expressing thick-tufted pyramidal neurons	adaptation percent (1 – first/last ISI)	17.0 ± 2.0 (27)	17.0 (ratio)	Data Table
Neocortex pyramidal cell layer 5-6	Somatosensory cortex layer 5b Glt25d2-expressing thick-tufted pyramidal neurons	adaptation ratio (other)	1.1 ± 0.3 (27)	1.1 (None)	Data Table
Neocortex pyramidal cell layer 2-3	Somatosensory cortex layer 2/3 pyramidal neurons	FI slope (2 s)	55.0 ± 7.0 (15)	--	Data Table
Neocortex pyramidal cell layer 2-3	Somatosensory cortex layer 2/3 pyramidal neurons	adaptation percent (1 – first/last ISI)	52.0 ± 4.0 (15)	52.0 (ratio)	Data Table
Neocortex pyramidal cell layer 2-3	Somatosensory cortex layer 2/3 pyramidal neurons	adaptation ratio (other)	24.0 ± 14.0 (15)	24.0 (None)	Data Table