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Article: Electrophysiological properties of genetically identified subtypes of layer 5 neocortical pyramidal neurons: Ca²⁺ dependence and differential modulation by norepinephrine.

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Guan D; Armstrong WE; Foehring RC
J. Neurophysiol., 2015


Table 5.

Voltage clamp of the mAHP and sAHP currents

Tail, pAτmediumτslow% Slow τ
Etv1259 ± 17 (14)66 ± 10 (14)933 ± 101 (14)52 ± 4 (14)
Glt372 ± 30 (14)*74 ± 11 (14)791 ± 75 (14)18 ± 4 (14)*
Layer 2/3227 ± 26 (21)149 ± 18 (21)2611 ± 550 (21)16 ± 2 (21)
  • Data are presented as means ± SE (n, number of cells). Currents were elicited by a 200-ms voltage step from -70 mV to +30 mV. Tail currents were measured upon a step to -60 mV. Tail is the difference between the initial and final amplitude of the tail current at -60 mV; tail currents were fit with the sum of 2 time (τ) constants (τmedium and τslow). τmedium is the faster τ component corresponding to the medium AHP (mAHP) current (ImAHP). τslow is τ for the sAHP current (IsAHP). % Slow τ is the percentage of tail amplitude accounted for by τslow.

  • * Significant difference glt from etv1 (P < 0.05, t-test).

  • Significant difference vs. layer 2/3 (ANOVA with Tukey's post hoc test).


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