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Article: Intrinsic excitability varies by sex in prepubertal striatal medium spiny neurons.

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Dorris DM; Cao J; Willett JA; Hauser CA; Meitzen J
J. Neurophysiol., 2015


Table 1.

Electrophysiological properties of male and female medium spiny neurons

PropertyMaleFemaleStatistics (t/U, P)
Resting potential, mV-81.2 ± 0.9 (33)-80.0 ± 1.2 (31)0.52, 0.40
Input resistance, MΩ448 ± 42 (33)465 ± 42 (31)484, 0.72
Time constant of the membrane, ms23 ± 1 (33)27 ± 2 (31)1.74, 0.08
Capacitance, pF61 ± 4 (33)69 ± 7 (31)476, 0.64
Rectified range input Resistance, MΩ289 ± 29 (33)291 ± 26 (31)499, 0.87
Inward rectification, MΩ156 ± 18 (33)175 ± 19 (31)0.72, 0.47
% Inward rectification, %67 ± 2 (33)65 ± 2 (31)0.86, 0.39
Sag index0.01 ± 0.00 (33)0.01 ± 0.00 (31)501, 0.89
AP threshold, mV-54 ± 1 (33)-58 ± 1 (30)2.09, 0.040
AP amplitude, mV72 ± 2 (33)75 ± 2 (30)1.26, 0.21
AP width at half-peak, ms2.6 ± 0.1 (33)2.6 ± 0.l (30)0.27, 0.78
AHP peak, mV-10.8 ± 0.7 (33)-8.3 ± 0.4 (30)3.04, 0.004
AHP time to peak, ms52.9 ± 2.9 (33)47.9 ± 4.1 (30)1.18, 0.24
Delay to first spike, ms313 ± 15 (33)307 ± 19 (30)0.24, 0.81
Rheobase, nA0.040 ± 0.008 (33)0.025 ± 0.004 (30)356, 0.053
FI slope, Hz/nA312.1 ± 18.5 (33)395.2 ± 20.4 (30)3.03, 0.004
  • Values are means ± SE. Numbers in parentheses indicate sample size. The sag index is unitless. None of these neurons fired spontaneous action potentials. Statistical differences between groups are depicted in boldface. Data were analyzed with t-tests or Mann-Whitney U-tests as appropriate.

  • AP, action potential; AHP, afterhyperpolarization; FI, frequency of evoked spikes to injected depolarization current.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neostriatum medium spiny neuron membrane time constant (ms) 23.0 ± 1.0 (33) 23.0 (ms) Data Table
Neostriatum medium spiny neuron membrane time constant (ms) 27.0 ± 2.0 (31) 27.0 (ms) Data Table
Neostriatum medium spiny neuron cell capacitance (pF) 61.0 ± 4.0 (33) 61.0 (pF) Data Table
Neostriatum medium spiny neuron cell capacitance (pF) 69.0 ± 7.0 (31) 69.0 (pF) Data Table
Neostriatum medium spiny neuron resting membrane potential (mV) -81.2 ± 0.9 (33) -81.2 (mV) Data Table
Neostriatum medium spiny neuron resting membrane potential (mV) -80.0 ± 1.2 (31) -80.0 (mV) Data Table
Neostriatum medium spiny neuron sag ratio 0.01 (33) 0.01 (ratio) Data Table
Neostriatum medium spiny neuron sag ratio 0.01 (31) 0.01 (ratio) Data Table
Neostriatum medium spiny neuron spike threshold (mV) -54.0 ± 1.0 (33) -54.0 (mV) Data Table
Neostriatum medium spiny neuron spike threshold (mV) -58.0 ± 1.0 (30) -58.0 (mV) Data Table
Neostriatum medium spiny neuron spike amplitude (mV) 72.0 ± 2.0 (33) 72.0 (mV) Data Table
Neostriatum medium spiny neuron spike amplitude (mV) 75.0 ± 2.0 (30) 75.0 (mV) Data Table
Neostriatum medium spiny neuron spike half-width (ms) 2.6 ± 0.1 (33) 2.6 (ms) Data Table
Neostriatum medium spiny neuron spike half-width (ms) 2.6 (30) 2.6 (ms) Data Table
Neostriatum medium spiny neuron AHP amplitude (mV) -10.8 ± 0.7 (33) 10.8 (mV) Data Table
Neostriatum medium spiny neuron AHP amplitude (mV) -8.3 ± 0.4 (30) 8.3 (mV) Data Table
Neostriatum medium spiny neuron AHP duration (ms) 52.9 ± 2.9 (33) 52.9 (ms) Data Table
Neostriatum medium spiny neuron AHP duration (ms) 47.9 ± 4.1 (30) 47.9 (ms) Data Table
Neostriatum medium spiny neuron first spike latency (ms) 313.0 ± 15.0 (33) 313.0 (ms) Data Table
Neostriatum medium spiny neuron first spike latency (ms) 307.0 ± 19.0 (30) 307.0 (ms) Data Table
Neostriatum medium spiny neuron rheobase (nA) 0.04 ± 0.008 (33) 40.0 (pA) Data Table
Neostriatum medium spiny neuron rheobase (nA) 0.025 ± 0.004 (30) 25.0 (pA) Data Table
Neostriatum medium spiny neuron input resistance (MΩ) 448.0 ± 42.0 (33) 448.0 (MΩ) Data Table
Neostriatum medium spiny neuron FI slope (Hz/nA) 312.1 ± 18.5 (33) 312.1 (Hz/nA) Data Table
Neostriatum medium spiny neuron FI slope (Hz/nA) 395.2 ± 20.4 (30) 395.2 (Hz/nA) Data Table
Neostriatum medium spiny neuron input resistance (MΩ) 465.0 ± 42.0 (31) 465.0 (MΩ) Data Table