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Article: Contribution of near-threshold currents to intrinsic oscillatory activity in rat medial entorhinal cortex layer II stellate cells.

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Boehlen A; Henneberger C; Heinemann U; Erchova I
J. Neurophysiol., 2013


Table 1.

Effects of the H-current blocker ZD7288, Cs+, and 8-bromo-cAMP on somatic passive and active properties in layer II stellate cells

Cell PropertiesControl (Patch)ZD7288 (Patch)Control (Sharp)Cs+ (Sharp)Control (Sharp)8-Bromo-cAMP (Sharp)
RMP, mV-61.4 ± 0.9-76.1 ± 1.7 (9)-65.8 ± 0.5-68.8 ± 1.1* (8)-64.6 ± 0.8-61.9 ± 0.7* (7)
Rinput, MΩ53.1 ± 5.1123.6 ± 10.2 (9)31.7 ± 4.140.3 ± 4.7* (8)31.9 ± 4.827.7 ± 4.9 (7)
Time constant at -100 pA, ms11.7 ± 0.820.9 ± 1.6 (9)11.9 ± 1.112.9 ± 1.3 (8)10.6 ± 0.611.5 ± 0.8
Voltage threshold, mV-43.1 ± 0.4-40.9 ± 0.6 (9)-54.3 ± 0.8-54.9 ± 1.6 (8)-53.9 ± 1.0-49.6 ± 1.5* (7)
Rheobase, pA181.1 ± 24.5235.6 ± 29.0 (9)172.8 ± 28.7233.5 ± 26.0 (8)186.7 ± 33.9283.7 ± 54.6 (7)
Spike latency, ms111.6 ± 29.0321.2 ± 41.8 (9)18.1 ± 1.313.0 ± 1.4* (8)20.7 ± 3.313.16 ± 2.1
Sag-tau, ms23.4 ± 2.9nd21.2 ± 1.440.1 ± 4.2 (8)21.4 ± 2.017.8 ± 2.6 (7)
Sag ratio at -400 pA0.07 ± 0.010.95 ± 0.01 (9)0.065 ± 0.030.96 ± 0.01 (8)0.08 ± 0.020.08 ± 0.03 (7)
Sag ratio at -200 pA0.7 ± 0.10.98 ± 0.15 (9)
fAHP amplitude, mV-7.6 ± 0.8-3.9 ± 1.1 (9)-10.0 ± 0.611.0 ± 0.6 (8)-9.4 ± 0.4-10.4 ± 0.7 (7)
DAP amplitude, mV1.3 ± 0.30.2 ± 0.1 (9)0.6 ± 0.41.7 ± 1.5 (2)0.7 ± 0.42.7 ± 0.5 (3)
mAHP amplitude, mV-10.0 ± 0.6-10.7 ± 0.6 (9)-5.7 ± 1.2-5.5 ± 0.7-4.6 ± 0.4-4.7 ± 0.7
mAHP amplitude DAP, mV-3.3 ± 0.6-4.5 ± 1.0 (6)
mAHP duration, ms71 ± 13133 ± 27* (6)26.2 ± 1.521.6 ± 0.6 (8)26.7 ± 2.420.2 ± 2.4* (7)
AP amplitude. mV75.4 ± 2.867.0 ± 3.7 (5)72.1 ± 1.070.6 ± 1.071.7 ± 1.069.7 ± 1.0
AP time to peak, ms0.58 ± 0.020.54 ± 0.02 (5)
AP half-width, ms0.70 ± 0.030.82 ± 0.06* (5)
AP voltage peak, mV32.2 ± 2.626.0 ± 3.8* (5)
No. of spikes
    At 100 pA0.1 ± 0.10 ± 0 (9)0.0 ± 0.00.0 ± 0.00.0 ± 0.00.0 ± 0.0
    At 200 Pa3.3 ± 0.90.6 ± 0.3* (9)0.4 ± 0.30.4 ± 0.30.0 ± 0.00.0 ± 0.0
    At 300 pA7.7 ± 1.53.6 ± 0.7* (9)2.0 ± 0.51.2 ± 0.41.3 ± 0.30.3 ± 0.3
    At 400 pA11.4 ± 1.56.0 ± 0.9 (9)4.0 ± 0.63.4 ± 0.63.0 ± 0.60.7 ± 0.7
  • Values are means ± SE (n = no. of observations) for effects of the H-current blocker ZD7288 (20 μM), cesium (Cs+; 1 mM), and the second messenger cyclic adenosine monophosphate (8-bromo-cAMP; 1 mM) on somatic passive and active properties in layer II stellate cells. Data were obtained using either whole cell patch-clamp (patch) or sharp microelectrode (sharp) recording techniques. AP, action potential; DAP, depolarizing afterpotential; fAHP, fast afterhyperpolarization; mAHP, medium afterhyperpolarization; Rinput, input resistance; RMP, resting membrane potential; sag, depolarization after an initial hyperpolarization.

  • * P < 0.05;

  • P < 0.01;

  • P < 0.001; nd, not detectable.


Report miscurated data

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Medial entorhinal cortex layer II stellate cell spike amplitude (mV) 75.4 ± 2.8 (66) 75.4 (mV) Data Table
Medial entorhinal cortex layer II stellate cell spike amplitude (mV) 72.1 ± 1.0 (26) 72.1 (mV) Data Table
Medial entorhinal cortex layer II stellate cell spike amplitude (mV) 71.7 ± 1.0 (26) 71.7 (mV) Data Table
Medial entorhinal cortex layer II stellate cell spike rise time (ms) 0.58 ± 0.02 (66) 0.58 (ms) Data Table
Medial entorhinal cortex layer II stellate cell input resistance (MΩ) 31.7 ± 4.1 (26) 31.7 (MΩ) Data Table
Medial entorhinal cortex layer II stellate cell spike half-width (ms) 0.7 ± 0.03 (66) 0.7 (ms) Data Table
Medial entorhinal cortex layer II stellate cell spike peak (mV) 32.2 ± 2.6 (66) 32.2 (mV) Data Table
Medial entorhinal cortex layer II stellate cell input resistance (MΩ) 31.9 ± 4.8 (26) 31.9 (MΩ) Data Table
Medial entorhinal cortex layer II stellate cell membrane time constant (ms) 11.7 ± 0.8 (66) 11.7 (ms) Data Table
Medial entorhinal cortex layer II stellate cell membrane time constant (ms) 11.9 ± 1.1 (26) 11.9 (ms) Data Table
Medial entorhinal cortex layer II stellate cell resting membrane potential (mV) -61.4 ± 0.9 (66) -61.4 (mV) Data Table
Medial entorhinal cortex layer II stellate cell membrane time constant (ms) 10.6 ± 0.6 (26) 10.6 (ms) Data Table
Medial entorhinal cortex layer II stellate cell spike threshold (mV) -43.1 ± 0.4 (66) -43.1 (mV) Data Table
Medial entorhinal cortex layer II stellate cell spike threshold (mV) -54.3 ± 0.8 (26) -54.3 (mV) Data Table
Medial entorhinal cortex layer II stellate cell spike threshold (mV) -53.9 ± 1.0 (26) -53.9 (mV) Data Table
Medial entorhinal cortex layer II stellate cell rheobase (pA) 181.1 ± 24.5 (66) 181.1 (pA) Data Table
Medial entorhinal cortex layer II stellate cell rheobase (pA) 172.8 ± 28.7 (26) 172.8 (pA) Data Table
Medial entorhinal cortex layer II stellate cell rheobase (pA) 186.7 ± 33.9 (26) 186.7 (pA) Data Table
Medial entorhinal cortex layer II stellate cell first spike latency (ms) 111.6 ± 29.0 (66) 111.6 (ms) Data Table
Medial entorhinal cortex layer II stellate cell first spike latency (ms) 18.1 ± 1.3 (26) 18.1 (ms) Data Table
Medial entorhinal cortex layer II stellate cell resting membrane potential (mV) -65.8 ± 0.5 (26) -65.8 (mV) Data Table
Medial entorhinal cortex layer II stellate cell first spike latency (ms) 20.7 ± 3.3 (26) 20.7 (ms) Data Table
Medial entorhinal cortex layer II stellate cell sag ratio (pA) 0.07 ± 0.01 (66) -- Data Table
Medial entorhinal cortex layer II stellate cell sag ratio (pA) 0.065 ± 0.03 (26) -- Data Table
Medial entorhinal cortex layer II stellate cell sag ratio (pA) 0.08 ± 0.02 (26) -- Data Table
Medial entorhinal cortex layer II stellate cell resting membrane potential (mV) -64.6 ± 0.8 (26) -64.6 (mV) Data Table
Medial entorhinal cortex layer II stellate cell fast AHP amplitude (mV) -7.6 ± 0.8 (66) 7.6 (mV) Data Table
Medial entorhinal cortex layer II stellate cell fast AHP amplitude (mV) -10.0 ± 0.6 (26) 10.0 (mV) Data Table
Medial entorhinal cortex layer II stellate cell fast AHP amplitude (mV) -9.4 ± 0.4 (26) 9.4 (mV) Data Table
Medial entorhinal cortex layer II stellate cell medium AHP amplitude (mV) -10.0 ± 0.6 (66) 10.0 (mV) Data Table
Medial entorhinal cortex layer II stellate cell medium AHP amplitude (mV) -5.7 ± 1.2 (26) 5.7 (mV) Data Table
Medial entorhinal cortex layer II stellate cell medium AHP amplitude (mV) -4.6 ± 0.4 (26) 4.6 (mV) Data Table
Medial entorhinal cortex layer II stellate cell input resistance (MΩ) 53.1 ± 5.1 (66) 53.1 (MΩ) Data Table
Medial entorhinal cortex layer II stellate cell medium AHP duration (ms) 71.0 ± 13.0 (66) 71.0 (ms) Data Table
Medial entorhinal cortex layer II stellate cell medium AHP duration (ms) 26.2 ± 1.5 (26) 26.2 (ms) Data Table
Medial entorhinal cortex layer II stellate cell medium AHP duration (ms) 26.7 ± 2.4 (26) 26.7 (ms) Data Table