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Article: Contribution of near-threshold currents to intrinsic oscillatory activity in rat medial entorhinal cortex layer II stellate cells.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Boehlen A; Henneberger C; Heinemann U; Erchova I J. Neurophysiol., 2013
Table 3.
Effects of the Kv7/KCNQ/M-channel activators ICAGEN-110381 and retigabine and Kv7/KCNQ/M-channel blocker XE991 on somatic passive and active properties in layer II stellate cells
| Cell properties | Control | ICA | Control | RTG | Control | XE991 |
|---|---|---|---|---|---|---|
| RMP, mV | -59.0 ± 0.9 | -60.0 ± 1.4* (11) | -57.6 ± 1.1 | -60.8 ± 1.4† (8) | -60.4 ± 0.8 | -57.6 ± 1.0† (10) |
| Rinput, MΩ | 50.5 ± 3.5 | 42.3 ± 2.2* (12) | 50.5 ± 2.7 | 52.8 ± 3.3 (8) | 48.3 ± 3.9 | 45.7 ± 3.9 (10) |
| Time constant at -100 pA, ms | 13.4 ± 1.0 | 13.9 ± 1 (11) | 12.5 ± 1.0 | 10.8 ± 1.4† (8) | 12.3 ± 0.5 | 14.0 ± 0.7† (10) |
| Voltage threshold, mV | -42.2 ± 0.9 | -37.1 ± 1.3‡ (12) | -42.5 ± 0.6 | -37.7 ± 2.4 (8) | -43.4 ± 0.6 | -41.3 ± 1.1 (10) |
| Rheobase, pA | 153.3 ± 19.2 | 330.2 ± 29.9‡ (12) | 135.0 ± 11.5 | 271.3 ± 42.3† (8) | 155.0 ± 19.7 | 163.0 ± 23.4 (10) |
| Spike latency, ms | 60.1 ± 3.7 | 51.8 ± 4.7 (11) | 69.1 ± 10.7 | 59.3 ± 17.5† (8) | 59.7 ± 5.5 | 118.6 ± 23.0* (10) |
| fAHP amplitude, mV | -7.2 ± 0.6 | -7.0 ± 0.8 (12) | -6.9 ± 0.7 | -7.5 ± 0.3 (6) | -7.0 ± 0.4 | -4.0 ± 0.4‡ (10) |
| DAP amplitude, mV | 1.6 ± 0.3 | 0.6 ± 0.3‡ (12) | 2.4 ± 0.5 | 1.5 ± 0.2 (6) | 1.5 ± 0.3 | 0.6 ± 0.2‡ (10) |
| mAHP amplitude (mV) | -8.6 ± 0.4 | -10.7 ± 0.7† (12) | -8.9 ± 0.5 | -9.6 ± 0.8 (7) | -8.6 ± 0.5 | -7.8 ± 0.7 (10) |
| mAHP amplitude DAP, mV | -3.7 ± 0.5 | -3.9 ± 0.9 (12) | -4.4 ± 0.3 | -3.5 ± 2.0 (6) | -3.8 ± 0.5 | -4.4 ± 0.4 (10) |
| mAHP duration, ms | 75.7 ± 9.5 | 121.14 ± 26.1 (8) | 80.6 ± 16.3 | 109.6 ± 67.9 (3) | 71.3 ± 8.5 | 113.9 ± 12.7* (7) |
| AP amplitude, mV | 72.8 ± 2.4 | 68.3 ± 2.2* (12) | 73.7 ± 1.0 | 65.9 ± 1.1† (7) | 79.2 ± 2.4 | 73.9 ± 2.2 (7) |
| AP time to peak, ms | 0.67 ± 0.02 | 0.68 ± 0.04 (12) | 0.65 ± 0.02 | 0.72 ± 0.01† (7) | 0.66 ± 0.02 | 0.73 ± 0.04 (7) |
| AP half-width, ms | 0.86 ± 0.02 | 0.94 ± 0.04* (12) | 0.89 ± 0.02 | 0.94 ± 0.03* (7) | 0.84 ± 0.02 | 0.93 ± 0.02 (7) |
| AP voltage peak, mV | 30.5 ± 2.0 | 31.4 ± 1.8 (12) | 30.8 ± 2.0 | 26.2 ± 1.4* (7) | 36.1 ± 2.4 | 32.3 ± 2.5 (7) |
| No. of spikes | ||||||
| At 100 pA | 0.7 ± 0.4 | 0 ± 0 (12) | 0.4 ± 0.3 | 0 ± 0 (8) | 0.4 ± 0.4 | 0.7 ± 0.5 (10) |
| At 200 pA | 3.6 ± 0.9 | 0.1 ± 0.1† (12) | 3.8 ± 0.9 | 1.0 ± 0.7* (8) | 4.3 ± 1.1 | 4.4 ± 1.2 (10) |
| At 300 pA | 6.8 ± 1.0 | 0.8 ± 0.3‡ (12) | 8.4 ± 0.6 | 2.6 ± 1.1† (8) | 8.9 ± 1.4 | 7.9 ± 1.4 (10) |
| At 400 pA | 10.2 ± 1.0 | 1.5 ± 0.5‡ (11) | 11.4 ± 0.6 | 4.0 ± 1.7† (8) | 12.4 ± 1.4 | 10.9 ± 1.3 (10) |
Values are means ± SE (n = no. of observations) for effects of the Kv7/KCNQ/M-channel activators ICAGEN-110381 (ICA; 10 μM) and retigabine (RTG; 1 μM) and the Kv7/KCNQ/M-channel blocker XE991 (10 μM) on somatic passive and active properties in layer II stellate cells. All data were obtained using the patch-clamp technique.
↵* P < 0.05;
↵† P < 0.01;
↵‡ P < 0.001.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|