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Article: Intrinsic neurophysiological properties of hilar ectopic and normotopic dentate granule cells in human temporal lobe epilepsy and a rat model.

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Althaus AL; Sagher O; Parent JM; Murphy GG
J. Neurophysiol., 2015


Table 2.

Passive membrane properties of all cells recorded from rodents displayed features of DGCs

Normotopic SEEctopic SENormotopic Sham
n3876
Resting membrane potential*, mV-71.62 ± 0.65-65.22 ± 3.15-71.57 ± 1.37
Input resistance, MΩ282.50 ± 31.65273.45 ± 31.75226.0 ± 32.71
Sag ratio1.005 ± 0.0010.999 ± 0.0021.003 ± 0.001
Action potential threshold, mV-40.79 ± 1.20-41.07 ± 2.59-37.87 ± 2.29
Action potential spike height, mV72.04 ± 2.9363.48 ± 4.8467.49 ± 6.53
Action potential half-width (ms)*0.99 ± 0.031.3 ± 0.140.95 ± 0.07
  • Values are means ± SE; n, no. of cells. SE, status epilepticus. Ectopic DGCs had depolarized resting membrane potential and wider action potential than normotopic or sham DGCs, respectively. Analyses were done using one-way ANOVA with Tukey's post hoc test for multiple comparisons.

  • * Main effect determined by one-way ANOVA.

  • Significantly different from normotopic SE with post hoc analysis.

  • Significantly different from sham with post hoc analysis.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dentate gyrus granule cell Dentate gyrus normotopic granule cell layer resting membrane potential (mV) -71.57 ± 1.37 (6) -71.57 (mV) Data Table
Dentate gyrus granule cell Dentate gyrus normotopic granule cell layer input resistance (MΩ) 226.0 ± 32.71 (6) 226.0 (MΩ) Data Table
Dentate gyrus granule cell Dentate gyrus normotopic granule cell layer sag ratio 1.003 ± 0.001 (6) 1.003 (ratio) Data Table
Dentate gyrus granule cell Dentate gyrus normotopic granule cell layer spike threshold (mV) -37.87 ± 2.29 (6) -37.87 (mV) Data Table
Dentate gyrus granule cell Dentate gyrus normotopic granule cell layer spike amplitude (mV) 67.49 ± 6.53 (6) 67.49 (mV) Data Table
Dentate gyrus granule cell Dentate gyrus normotopic granule cell layer spike half-width (ms) 0.95 ± 0.07 (6) 0.95 (ms) Data Table