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Article: Examining protection from anoxic depolarization by the drugs dibucaine and carbetapentane using whole-cell recording from CA1 neurons.

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J. Neurophysiol., 2012


Table 4.

Drug effects on the intrinsic properties of CA1 neurons

Control (n = 45)3 μM Dib (n = 9)10 μM CP (n = 12)30 μM CP (n = 11)100 μM CP (n = 5)3 μM Dib and 30 μM CP (n = 11)
RMP, mV-62.5 ± 3.0-59.7 ± 3.0-62.4 ± 3.2-65.6 ± 3.1-64.0 ± 2.6-63.5 ± 3.7
fAHP, mV-3.4 ± 1.9-2.7 ± 1.7Absent* (11/12)Absent*Absent*Absent*
AP threshold, mV-47.5 ± 4.4-46.0 ± 3.8-47.7 ± 2.7-49.1 ± 2.8-47.0 ± 3.4-38.8 ± 4.6†
AP freq (0.1 nA), Hz12.7 ± 9.512.3 ± 9.56.8 ± 4.4 *6.0 ± 2.1*1.2 ± 1.3†0.5 ± 0.8†
AP freq (0.2 nA), Hz24.3 ± 9.534.2 ± 16.413.2 ± 4.2†9.4 ± 2.5†1.6 ± 0.9†2.3 ± 1.8†
AP freq (0.3 nA), Hz31.5 ± 8.7N/A16.8 ± 5.1†11.4 ± 2.8†2.2 ± 1.1†2.9 ± 2.3†
AP ampl, mV89.6 ± 10.070 ± 21.5*82.3 ± 14.474.9 ± 15.4*62.5 ± 15.0†70.5 ± 10.2*
AP dur (½ ampl), ms1.0 ± 0.11.0 ± 0.21.0 ± 0.11.4 ± 0.9*2.0 ± 2.6†1.3 ± 0.2*
Rin, MΩ47.4 ± 8.446.6 ± 1.745.8 ± 6.366.8 ± 17.2*80.9 ± 16.9†57.5 ± 11.5*

  • Values are means ± SD.

  • ↵* P < 0.05;

  • ↵† P < 0.01. CP, carbetapentane; RMP, resting membrane potential; fAHP, fast afterhyperpolarization; AP, action potential; freq, frequency; dur (½ ampl), AP duration at ½ of AP amplitude; Rin, input resistance; N/A, not applicable.


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