Table 1: Properties of P35 wild-type and a6 -/- GCs
Wild-type
a6 -/-
Membrane properties
Resting potential (mV)
-78.2 ± 0.9
-75.5 ± 1.1
Input conductance (nS)
1.1 ± 0.1
0.8 ± 0.1
Action potentials
Threshold (mV)
-34.7 ± 1.1
-34.0 ± 1.4
Amplitude (mV)
81.2 ± 1.5
79.9 ± 1.8
10±90% rise time (μs)
223 ± 8
215 ± 7
Half-width (μs)
434 ± 12
425 ± 10
Peak after hyperpolarization (mV)
-67.4 ± 0.8
-67.1 ± 1.5
Action potential threshold current (pA)
25.3 ± 2.7
26.2 ± 6.0
Action potential frequency at +40 pA (Hz)
35.8 ± 9.4
36.1 ± 11.3
Action potential frequency versus current (Hz/pA)
1.89
1.71
All values are mean +\- s.e.m. Resting membrane potential (zero current potential) was measured within 1 min of establishing whole-cell recording. Input conductance was measured from the steady-state voltage response to a -2 pA current injection. Membrane and action potential properties were determined from 25 wild-type and 26 a6 -/- GCs (except for action potential frequency at +40 pA and action potential frequency versus current, where n = 5 and 13, respectively). EPSCs were recorded from five wild-type and four a6 -/- GCs. EPSPs were from seven wild-type and six a6 -/- GCs.:
