Article: Tuning of fast-spiking interneuron properties by an activity-dependent transcriptional switch.
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Dehorter N; Ciceri G; Bartolini G; Lim L; del Pino I; Marín O
Science, 2015
Figure S5: Embryonic deletion of Er81 from PV+ interneurons impacts their intrinsic properties.
|
Lhx6-Cre;Er81+/+ |
Lhx6-Cre;Er81F/F |
P values |
| Vrest (mV) |
-70.1 +/- 1.7 |
-71.3 +/- 1.6 |
0.61 |
| Cm (pF) |
31.2 +/- 2.3 |
32.8 +/- 3.5 |
0.69 |
| Rm (MOhm) |
134 +/- 9.7 |
165.3 +/- 13.3 |
0.06 |
| Rheobase (pA) |
193.5 +/- 26.1 |
122.6 +/- 19.1 |
(*) .04 |
| V threshold (mV) |
-36.9 +/- 1.0 |
-43.2 +/- 2.2 |
(**) 0.009 |
| AP amplitude (mV) |
52.3 +/- 2.2 |
52.2 +/- 2.9 |
0.97 |
| AP rise duration (ms) |
0.22 +/- .01 |
0.27 +/- .02 |
(*) .02 |
| AP tot duration (ms) |
0.71 +/- 0.03 |
0.90 +/- .05 |
(**) .002 |
| AHP amplitude (mV) |
21.56 +/- .77 |
18.56 +/- 1.41 |
(*) 0.04 |
| AHP duration (ms) |
0.12 +/- .01 |
0.15 +/- .01 |
0.07 |
| Latency to the 1st spike (ms) |
236.4 +/- 28.8 |
138.8 +/- 20.8 |
(*) 0.01 |
| Exponential fit (mV) |
3.8 +/- .06 |
2.1 +/- .06 |
(*) 0.04 |
| MFF (Hz) |
164.9 +/- 16.7 |
142.7 +/- 10.9 |
0.25 |
| Number of cells |
20 |
18 |
|
| (D) Intrinsic electrophysiological properties of PV+ interneurons in cortical layer II-III of control and Lhx6-Cre;Er81 conditional mutants. Vrest: resting membrane potential; Cm: membrane capacitance; Rm: membrane resistance; Vthreshold: Threshold potential for spike; AP: Action potential; AHP: After hyperpolarization; MFF: Maximum firing frequency. Graphs represent mean +\- s.e.m.: |
Inferred neuron-electrophysiology data values
| Neuron Type |
Neuron Description |
Ephys Prop |
Extracted Value |
Standardized Value |
Content Source |
