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Article: Region-specific spike-frequency acceleration in layer 5 pyramidal neurons mediated by Kv1 subunits.

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Miller MN; Okaty BW; Nelson SB
J. Neurosci., 2008


Table 1: The intrinsic membrane properties and firing types of PT-projecting layer 5 pyramidal cells in primary motor cortex in the presence of ACSF and DTX (curated from article text around Figure 3 and 4)
ISI ratio resting Vm RIn action potential half-width rheobase AP threshold
M1 YFPH/PT cells, ACSF (n = 8) 1.57 -69.3 97.3 1.01 367 -46.02
M1 YFPH/PT cells, DTX( n = 8) 1.08 -68.1 101.8 0.99 271 -48.60
We directly tested this hypothesis by measuring the degree of spike-frequency acceleration in M1 YFPH/PT cells before and after bath application of DTX (figure 4). 100 nM DTX significantly reduced the ISI ratio in M1 YFPH/PT cells from 1.57 to 1.08 (n=8, p

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 primary motor cortex layer 5 corticospinal thick tufted pyramidal cell adaptation ratio 1.57 (8) 1.57 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 primary motor cortex layer 5 corticospinal thick tufted pyramidal cell resting membrane potential -69.3 (8) -69.3 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary motor cortex layer 5 corticospinal thick tufted pyramidal cell input resistance 97.3 (8) 97.3 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 primary motor cortex layer 5 corticospinal thick tufted pyramidal cell spike half-width 1.01 (8) 1.01 (ms) Data Table
Neocortex pyramidal cell layer 5-6 primary motor cortex layer 5 corticospinal thick tufted pyramidal cell rheobase 367.0 (8) 367.0 (pA) Data Table
Neocortex pyramidal cell layer 5-6 primary motor cortex layer 5 corticospinal thick tufted pyramidal cell spike threshold -46.02 (8) -46.02 (mV) Data Table