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Article: Selective degeneration of a physiological subtype of spinal motor neuron in mice with SOD1-linked ALS.

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Hadzipasic M; Tahvildari B; Nagy M; Bian M; Horwich AL; McCormick DA
Proc. Natl. Acad. Sci. U.S.A., 2014


Table 1- From Supplementary Table 1: Intrinsic Passive and Active Properties of Lumbar Motor Neurons in Control and G85R SOD1YFP Animals
Vm (mV) Rm (M ohm) Tau (ms) SAG (%) APT (mV) APA (mV) ADP (ms) dV/dt Ratio SSF (Hz) FIF (Hz) AI
2.5 Months ChAT-eGFP
Cluster 1 -70 +/- 1 95 +/- 18 8.9 +/- 0.9 19 +/- 6 -50 +/- 2 74 +/- 3 0.26 +/- 0.01 -0.64 +/- 0.01 32 +/- 2 46 +/- 3 0.70 +/- 0.05
Cluster 2 -69 +/- 1 73 +/- 7 6.9 +/- 0.7 11 +/- 1 -50 +/- 1 69 +/- 2 0.34 +/- 0.03 -0.56 +/- 0.02 50 +/- 3 165 +/- 8 0.31 +/- 0.02
Cluster 3 -74 +/- 1 48 +/- 9 4.9 +/- 0.7 18 +/- 4 -50 +/- 1 69 +/- 2 0.36 +/- 0.03 -0.56 +/- 0.02 75 +/- 5 341 +/- 20 0.22 +/- 0.01
Cluster 4 -71 +/- 1 44 +/- 8 2.2 +/- 0.3 4 +/-1 -51 +/- 2 75 +/- 4 0.32 +/- 0.03 -0.55 +/- 0.02 171+/- 14 456 +/- 16 0.37 +/- 0.03
2.5 Months G85R SOD1YFP
Cluster 1 -68 +/- 1 81 +/- 8 9.1 +/- 1.0 16 +/- 2 -51 +/- 1 71 +/- 2 0.34 +/- 0.02 -0.57 +/- 0.03 44 +/- 13 46 +/- 5 0.68 +/- 0.04
Cluster 2 -70 +/- 1 84 +/- 12 8.4 +/- 1.0 15 +/- 4 -51 +/- 1 74 +/- 2 0.42 +/- 0.07 -0.59 +/- 0.04 45 +/- 3 122 +/- 4 0.38 +/- 0.03
Cluster 3 -73 +/- 1 42 +/- 3 3.9 +/- 0.5 6 +/- 1 -52 +/- 1 72 +/- 2 0.37 +/- 0.02 -0.54 +/- 0.01 85 +/- 5 354 +/- 20 0.24 +/- 0.01
Cluster 4 -77 +/- 1 30 +/- 4 3.6 +/- 0.4 5 +/- 3 -53 +/- 2 74 +/- 2 0.36 +/- 0.04 -0.57 +/- 0.02 148+/- 9 424 +/- 23 0.35 +/- 0.02
4 Months G85R SOD1YFP
Cluster 1 -68 +/- 1 87 +/- 9 8.9 +/- 1.0 15 +/- 3 -52 +/- 1 68 +/- 3 0.43 +/- 0.02 -0.55 +/- 0.02 30 +/- 2 52 +/- 5 0.60 +/- 0.03
Cluster 2 -75 +/- 1 107 +/- 15 10.1 +/- 1.0 16 +/- 3 -54 +/- 1 67 +/- 2 0.41 +/- 0.02 -0.59 +/- 0.03 54 +/- 4 136 +/- 8 0.41 +/- 0.03
Cluster 3 -77 +/- 1 43 +/- 5 3.9 +/- 0.3 10 +/- 3 -58 +/- 2 74 +/- 3 0.39 +/- 0.01 -0.59 +/- 0.02 83 +/- 7 329 +/- 22 0.26 +/- 0.02
Cluster 4 - - - - - - - - - - -
Vm, Membrane Potential; Rm, Input Resistance; Rin, Membrane Time Constant; SAG, Ratio of membrane potential at the beginning of a 255 mV 500 ms hyperpolarizing current pulse to membrane potential at the end of the pulse; APT, Action Potential Threshold; APA, Action Potential Amplitude; APD, Action Potential Duration at half-maximum width; dV/dt Ratio, Ratio of dV/dt at peak positive and negative values during an action potential; SSF, Steady State Firing frequency 500 ms into a current pulse of 3x rheobase; FIF, First Instantaneous Firing frequency to a current pulse of 3x rheobase; AI, Adaptation Index, SSF/FIF.:

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 1 motor neuron resting membrane potential (mV) -70.0 ± 1.0 (7) -70.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 1 motor neuron input resistance (M ohm) 95.0 ± 18.0 (7) 95.0 (MΩ) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 1 motor neuron membrane time constant (ms) 8.9 ± 0.9 (7) 8.9 (ms) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 1 motor neuron sag ratio 19.0 ± 6.0 (7) 0.19 (ratio) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 1 motor neuron spike threshold (mV) -50.0 ± 2.0 (7) -50.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 1 motor neuron spike amplitude (mV) 74.0 ± 3.0 (7) 74.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 1 motor neuron spike half-width (ms) 0.26 ± 0.01 (7) 0.26 (ms) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 1 motor neuron maximum firing rate (Hz) 32.0 ± 2.0 (7) 32.0 (Hz) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 1 motor neuron firing frequency (Hz) 46.0 ± 3.0 (7) 46.0 (Hz) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 1 motor neuron adaptation ratio 0.7 ± 0.05 (7) 0.7 (ratio) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 2 motor neuron resting membrane potential (mV) -69.0 ± 1.0 (18) -69.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 2 motor neuron input resistance (M ohm) 73.0 ± 7.0 (18) 73.0 (MΩ) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 2 motor neuron membrane time constant (ms) 6.9 ± 0.7 (18) 6.9 (ms) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 2 motor neuron sag ratio 11.0 ± 1.0 (18) 0.11 (ratio) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 2 motor neuron spike threshold (mV) -50.0 ± 1.0 (18) -50.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 2 motor neuron spike amplitude (mV) 69.0 ± 2.0 (18) 69.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 2 motor neuron spike half-width (ms) 0.34 ± 0.03 (18) 0.34 (ms) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 2 motor neuron maximum firing rate (Hz) 50.0 ± 3.0 (18) 50.0 (Hz) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 2 motor neuron firing frequency (Hz) 165.0 ± 8.0 (18) 165.0 (Hz) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 2 motor neuron adaptation ratio 0.31 ± 0.02 (18) 0.31 (ratio) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 3 motor neuron resting membrane potential (mV) -74.0 ± 1.0 (11) -74.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 3 motor neuron input resistance (M ohm) 48.0 ± 9.0 (11) 48.0 (MΩ) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 3 motor neuron membrane time constant (ms) 4.9 ± 0.7 (11) 4.9 (ms) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 3 motor neuron sag ratio 18.0 ± 4.0 (11) 0.18 (ratio) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 3 motor neuron spike threshold (mV) -50.0 ± 1.0 (11) -50.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 3 motor neuron spike amplitude (mV) 69.0 ± 2.0 (11) 69.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 3 motor neuron spike half-width (ms) 0.36 ± 0.03 (11) 0.36 (ms) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 3 motor neuron maximum firing rate (Hz) 75.0 ± 5.0 (11) 75.0 (Hz) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 3 motor neuron firing frequency (Hz) 341.0 ± 20.0 (11) 341.0 (Hz) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 3 motor neuron adaptation ratio 0.22 ± 0.01 (11) 0.22 (ratio) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 4 motor neuron resting membrane potential (mV) -71.0 ± 1.0 (6) -71.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 4 motor neuron input resistance (M ohm) 44.0 ± 8.0 (6) 44.0 (MΩ) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 4 motor neuron membrane time constant (ms) 2.2 ± 0.3 (6) 2.2 (ms) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 4 motor neuron sag ratio 4.0 ± 1.0 (6) 0.04 (ratio) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 4 motor neuron spike threshold (mV) -51.0 ± 2.0 (6) -51.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 4 motor neuron spike amplitude (mV) 75.0 ± 4.0 (6) 75.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 4 motor neuron spike half-width (ms) 0.32 ± 0.03 (6) 0.32 (ms) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 4 motor neuron maximum firing rate (Hz) 171.0 ± 14.0 (6) 171.0 (Hz) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 4 motor neuron firing frequency (Hz) 456.0 ± 16.0 (6) 456.0 (Hz) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 4 motor neuron adaptation ratio 0.37 ± 0.03 (6) 0.37 (ratio) Data Table