Table 1- From text around Figure 4 and Figure 4 le: Intrinsic action potential properties between Wt and Mecp2 null neurons.
Rin (M Ohm)
Cm (pF)
Vm (mV)
AP duration (ms)
AP amplitude (mV)
WT (n=5)
98 +/- 7.8
142 +/- 6.5
-65 +/- 0.8
2.70
81.5
Mecp2 null (n=5)
105 +/- 10
127 +/- 4.2
-63 +/- 1.2
2.73
83.3
(A) Representative voltage traces from Wt and Mecp2 null excitatory pyramidal layer 5 mPFC neurons in response to current injections. Individual action potential properties were analyzed (see dashed box and inset) to determine the amplitude and half-height spike duration (D) between Wt and Mecp2 null neurons. (B) Across the population of neurons examined (n = 5 neurons with 7 repeats per neuron for both Wt and Mecp2 null animals), spike duration was not significantly different between Wt and Mecp2 null neurons (mean duration = 2.70 and 2.73 ms, respectively). (C) There was a small but significant increase in the mean spike amplitude between Wt and Mecp2 null neurons (81.5 and 83.3 mV, respectively; P = 3e-17, Mann Whitney U-test).: