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Article: Electrophysiological heterogeneity of spinally projecting serotonergic and nonserotonergic neurons in the rostral ventromedial medulla.

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Zhang L; Sykes KT; Buhler AV; Hammond DL
J. Neurophysiol., 2006



TABLE 1.Passive membrane and action potential properties in serotonergic and nonserotonergic spinally projecting RVM neurons
Parameter Type 1
 Type 2
 Type 3
Non-5HT 5HT Non-5HT 5HT Non-5HT 5HT
Spontaneous activity 15/15 14/14 0/35 0/13 36/36 17/17
Membrane capacitance, pF 77.1 ± 9.3ab 56.7 ± 2.5c 102.2 ± 6.2a 85.7 ± 4.6d 73.3 ± 7.9b 62.4 ± 5.0c
Membrane resistance, MΩ 658.6 ± 109.6a 1095.9 ± 88.6c** 267.1 ± 25.8b 485.5 ± 40.3d** 707.0 ± 93.0a 1149.4 ± 165.7c*
Resting membrane potential, mV –48.1 ± 0.8a –50.7 ± 0.6c –56.6 ± 0.8b –67.2 ± 2.5d** NA NA
Action potential threshold, mV –36.5 ± 0.7a –35.2 ± 0.6c –36.1 ± 0.6a –37.5 ± 0.8c –37.7 ± 0.6a –36.9 ± 0.8c
Action potential amplitude, mV 91.9 ± 2.6a 97.3 ± 2.1c 82.7 ± 1.9b 101.6 ± 1.2c** 88.3 ± 1.6ab 96.1 ± 2.1c**
Action potential half-width, ms 0.77 ± 0.04ab 1.08 ± 0.04c** 0.67 ± 0.03a 1.08 ± 0.03c** 0.86 ± 0.04b 1.09 ± 0.03c**
Slow afterhyperpolarization amplitude, mV 21.1 ± 1.1 21.1 ± 1.0 NA NA NA NA
Action potential threshold to AHP maximum, mV 32.6 ± 0.9a 36.6 ± 1.2c* 30.3 ± 0.9ab 28.8 ± 1.2d 28.6 ± 0.8b 32.7 ± 1.6cd*
Presence of fast after hyperpolarization 7/15 1/14* 25/35 1/13** 20/36 1/17**
Values are means ± SE. NA, not applicable; RVM, rostral ventromedial medulla; 5HT, serotonin;

* P < 0.05

** P < 0.01 compared to corresponding class of nonserotonergic neuron a,b: comparisons among type 1, 2 and 3 nonserotonergic neurons; c,d: comparisons among type 1, 2 and 3 serotonergic neurons. Common superscripts indicate that the values do not differ from one another within that label category (serotonergic or nonserotonergic) as determined by one-way ANOVA or Kruskal-Wallis test.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Rostral ventromedial medulla nonserotonergic irregular spiking neurons cell capacitance (pF) 77.1 ± 9.3 (15) 77.1 (pF) Data Table
Other Rostral ventromedial medulla serotonergic irregular spiking neurons cell capacitance (pF) 56.7 ± 2.5 (14) 56.7 (pF) Data Table
Other Rostral ventromedial medulla nonserotonergic non-spiking neurons cell capacitance (pF) 102.2 ± 6.2 (35) 102.2 (pF) Data Table
Other Rostral ventromedial medulla serotonergic non-spiking neurons cell capacitance (pF) 85.7 ± 4.6 (13) 85.7 (pF) Data Table
Other Rostral ventromedial medulla nonserotonergic Rapid spiking neurons cell capacitance (pF) 73.3 ± 7.9 (36) 73.3 (pF) Data Table
Other Rostral ventromedial medulla Serotonergic Rapid spiking neurons cell capacitance (pF) 62.4 ± 5.0 (17) 62.4 (pF) Data Table
Other Rostral ventromedial medulla nonserotonergic irregular spiking neurons input resistance (MΩ) 658.6 ± 109.6 (15) 658.6 (MΩ) Data Table
Other Rostral ventromedial medulla serotonergic irregular spiking neurons input resistance (MΩ) 1095.9 ± 88.6 (14) 1095.9 (MΩ) Data Table
Other Rostral ventromedial medulla nonserotonergic non-spiking neurons input resistance (MΩ) 267.1 ± 25.8 (35) 267.1 (MΩ) Data Table
Other Rostral ventromedial medulla serotonergic non-spiking neurons input resistance (MΩ) 485.5 ± 40.3 (13) 485.5 (MΩ) Data Table
Other Rostral ventromedial medulla nonserotonergic Rapid spiking neurons input resistance (MΩ) 707.0 ± 93.0 (36) 707.0 (MΩ) Data Table
Other Rostral ventromedial medulla Serotonergic Rapid spiking neurons input resistance (MΩ) 1149.4 ± 165.7 (17) 1149.4 (MΩ) Data Table
Other Rostral ventromedial medulla nonserotonergic irregular spiking neurons resting membrane potential (mV) -48.1 ± 0.8 (15) -48.1 (mV) Data Table
Other Rostral ventromedial medulla serotonergic irregular spiking neurons resting membrane potential (mV) -50.7 ± 0.6 (14) -50.7 (mV) Data Table
Other Rostral ventromedial medulla nonserotonergic non-spiking neurons resting membrane potential (mV) -56.6 ± 0.8 (35) -56.6 (mV) Data Table
Other Rostral ventromedial medulla serotonergic non-spiking neurons resting membrane potential (mV) -67.2 ± 2.5 (13) -67.2 (mV) Data Table
Other Rostral ventromedial medulla nonserotonergic irregular spiking neurons spike threshold (mV) -36.5 ± 0.7 (15) -36.5 (mV) Data Table
Other Rostral ventromedial medulla serotonergic irregular spiking neurons spike threshold (mV) -35.2 ± 0.6 (14) -35.2 (mV) Data Table
Other Rostral ventromedial medulla nonserotonergic non-spiking neurons spike threshold (mV) -36.1 ± 0.6 (35) -36.1 (mV) Data Table
Other Rostral ventromedial medulla serotonergic non-spiking neurons spike threshold (mV) -37.5 ± 0.8 (13) -37.5 (mV) Data Table
Other Rostral ventromedial medulla nonserotonergic Rapid spiking neurons spike threshold (mV) -37.7 ± 0.6 (36) -37.7 (mV) Data Table
Other Rostral ventromedial medulla Serotonergic Rapid spiking neurons spike threshold (mV) -36.9 ± 0.8 (17) -36.9 (mV) Data Table
Other Rostral ventromedial medulla nonserotonergic irregular spiking neurons spike amplitude (mV) 91.9 ± 2.6 (15) 91.9 (mV) Data Table
Other Rostral ventromedial medulla serotonergic irregular spiking neurons spike amplitude (mV) 97.3 ± 2.1 (14) 97.3 (mV) Data Table
Other Rostral ventromedial medulla nonserotonergic non-spiking neurons spike amplitude (mV) 82.7 ± 1.9 (35) 82.7 (mV) Data Table
Other Rostral ventromedial medulla serotonergic non-spiking neurons spike amplitude (mV) 101.6 ± 1.2 (13) 101.6 (mV) Data Table
Other Rostral ventromedial medulla nonserotonergic Rapid spiking neurons spike amplitude (mV) 88.3 ± 1.6 (36) 88.3 (mV) Data Table
Other Rostral ventromedial medulla Serotonergic Rapid spiking neurons spike amplitude (mV) 96.1 ± 2.1 (17) 96.1 (mV) Data Table
Other Rostral ventromedial medulla nonserotonergic irregular spiking neurons spike half-width (ms) 0.77 ± 0.04 (15) 0.77 (ms) Data Table
Other Rostral ventromedial medulla serotonergic irregular spiking neurons spike half-width (ms) 1.08 ± 0.04 (14) 1.08 (ms) Data Table
Other Rostral ventromedial medulla nonserotonergic non-spiking neurons spike half-width (ms) 0.67 ± 0.03 (35) 0.67 (ms) Data Table
Other Rostral ventromedial medulla serotonergic non-spiking neurons spike half-width (ms) 1.08 ± 0.03 (13) 1.08 (ms) Data Table
Other Rostral ventromedial medulla nonserotonergic Rapid spiking neurons spike half-width (ms) 0.86 ± 0.04 (36) 0.86 (ms) Data Table
Other Rostral ventromedial medulla Serotonergic Rapid spiking neurons spike half-width (ms) 1.09 ± 0.03 (17) 1.09 (ms) Data Table
Other Rostral ventromedial medulla nonserotonergic irregular spiking neurons slow AHP amplitude (mV) 21.1 ± 1.1 (15) 21.1 (mV) Data Table
Other Rostral ventromedial medulla serotonergic irregular spiking neurons slow AHP amplitude (mV) 21.1 ± 1.0 (14) 21.1 (mV) Data Table
Other Rostral ventromedial medulla nonserotonergic irregular spiking neurons spike threshold (mV) 32.6 ± 0.9 (15) -32.6 (mV) Data Table
Other Rostral ventromedial medulla serotonergic irregular spiking neurons spike threshold (mV) 36.6 ± 1.2 (14) -36.6 (mV) Data Table
Other Rostral ventromedial medulla nonserotonergic non-spiking neurons spike threshold (mV) 30.3 ± 0.9 (35) -30.3 (mV) Data Table
Other Rostral ventromedial medulla serotonergic non-spiking neurons spike threshold (mV) 28.8 ± 1.2 (13) -28.8 (mV) Data Table
Other Rostral ventromedial medulla nonserotonergic Rapid spiking neurons spike threshold (mV) 28.6 ± 0.8 (36) -28.6 (mV) Data Table
Other Rostral ventromedial medulla Serotonergic Rapid spiking neurons spike threshold (mV) 32.7 ± 1.6 (17) -32.7 (mV) Data Table