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Article: Examining protection from anoxic depolarization by the drugs dibucaine and carbetapentane using whole-cell recording from CA1 neurons.

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J. Neurophysiol., 2012


Table 1.

Anoxic depolarization properties recorded in CA1 pyramidal cells evoked by oxygen/glucose deprivation

Control (n = 17) 10 μM Dib (n = 11) 100 μM Dib (n = 14) Effect
Fast AD ampl, mV 28.8 ± 6.2 26.1 ± 10.2 18.9 ± 6.9* Reduced
Peak potential, mV −9.4 ± 4.6 −15.4 ± 11.0 −23.4 ± 11.2 Reduced
Slope of fast AD, mV/s 2.7 ± 1.5 2.1 ± 1.6 1.5 ± 0.4* Reduced
Slope of slow depol, mV/s 0.28 ± 0.16 0.18 ± 0.06 0.16 ± 0.04* Reduced
Late AD duration, s 46.4 ± 31.3 73.2 ± 37.2* 124.5 ± 50.9 Increased
  • Values are means ± SD.

  • * P < 0.05;

  • P < 0.01. Dib, dibucaine; fast AD ampl, amplitude of fast component of anoxic depolarization (AD); peak potential, peak amplitude of the depolarization; slope of fast AD, slope of the fast component of AD; slope of slow depol, slope of slow component of depolarization; late AD duration, duration of the late or persistent depolarization.


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