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Article: Effects of temperature on calcium transients and Ca2+-dependent afterhyperpolarizations in neocortical pyramidal neurons.

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Lee JC; Callaway JC; Foehring RC
J. Neurophysiol., 2005



TABLE 3.Temperature effects on [Ca2+]i and the AHP in response to trains of APs
RT 32–34°C Q10
[Ca2+]i
    Amplitude, nM 235 ± 85 (13) 155 ± 61 (13) 0.63 ± 0.34
    τdecay of [Ca2+]i
    τ1 1128 ± 825 (10) * 389 ± 159 (11) 0.31 ± 0.26
    τ2 2429 ± 1423 (10) * 772 ± 293 (11) 0.28 ± 0.19
    Only single τ 929 ± 293 (3) * 452 ± 97 (17) 0.45 ± 0.17
    Integral, nM*s 137 ± 53 (13) * 53 ± 21 (24) 0.35 ± 0.19
sAHP
    Amplitude, mV 7.5 ± 3.3 (13) * 5.1 ± 2.0 (28) 0.65 ± 0.43
    TTP, ms 926 ± 441 (7) * 223 ± 101 (5) 0.20 ± 0.14
    τdecay 3746 ± 2593 (13) * 1522 ± 993 (28) 0.37 ± 0.35
IsAHP
    Amplitude, nA1 43 ± 28 (5) 47 ± 31 (7) 1.19 ± 1.10
    TTP, ms1 827 ± 203 (10) * 333 ± 172 (10) 0.21 ± 0.12
    τrise, ms1 225 ± 49 (5) * 122 ± 46 (7) 0.35 ± 0.15
    τdecay, ms1 3691 ± 1763 (5) * 1729 ± 1128 (12) 0.27 ± 0.22
    Integral, nA*s1 115 ± 78 (6) * 71 ± 52 (16) 0.41 ± 0.40
Trains consisted of 10 suprathreshold 5-ms current injections at 50 Hz. [Ca2+]i determined from dF/F using Eq. 1 in METHODS. [Ca2+]i amplitude, change from resting [Ca2+]i. Data for the Integral of IsAHP provide an indicator of total charge movement. AP, action potential; RT, 22–24°C; mAHP, medium afterhyperpolarization; TTP, time-to-peak; τ, time constant.

* , significant difference between temperatures (p < 0.05, unpaired t-test). 1IsAHP was measured in the presence of apamin (50–100 nM) to block ImAHP.


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