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Article: Long-term depression at parallel fiber to Golgi cell synapses.

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Robberechts Q; Wijnants M; Giugliano M; De Schutter E
J. Neurophysiol., 2010


Table 1.

Passive cell parameters and several EPSC parameters, shown per experimental group and pre- vs. post- induction protocol

C-clamp IP
(n = 19) 		V-clamp IP
(n = 7) 		NMDAR Block
(n = 10) 		40 mM BAPTA
(n = 9) 		Aspecific mGluR
(n = 4) 		mGluRII Block
(n = 7) 		mGluRI Block
(n = 3) 		PKA Block
(n = 6)
Rinput, Mohm 271 ± 37 322 ± 52 286 ± 38 255 ± 32 301 ± 61 320 ± 50 573 ± 210 402 ± 61
Cm, pF 131 ± 13 142 ± 46 152 ± 17 96 ± 30 123 ± 25 141 ± 22 62 ± 11 126 ± 22
Amplitude EPSCs, pA
    Pre-IP 243 ± 24 362 ± 51 277 ± 35 263 ± 27 300 ± 104 308 ± 23 279 ± 16 372 ± 40
    Post-IP 185 ± 22 253 ± 41 210 ± 36 210 ± 23 284 ± 82 308 ± 39 178 ± 6 361 ± 32
    P-value <0.01 <0.01 0.04 <0.01 0.38 0.86 0.02 0.55
PPR
    Pre-IP 2.06 ± 0.12 2.18 ± 0.17 1.93 ± 0.12 1.96 ± 0.24 2.12 ± 0.40 1.68 ± 0.06 1.75 ± 0.06 1.71 ± 0.2
    Post-IP 2.14 ± 0.15 2.34 ± 0.22 2.12 ± 0.16 1.88 ± 0.07 1.81 ± 0.26 1.75 ± 0.14 1.93 ± 0.13 1.70 ± 0.11
    P-value 0.57 0.27 0.17 0.24 0.14 0.5 0.10 0.91
Average slope, -pA/ms
    Pre-IP 1.77 ± 0.26 1.77 ± 0.31 1.63 ± 0.38 1.62 ± 0.22 1.14 ± 0.54 1.63 ± 0.15 1.98 ± 0.04 2.64 ± 0.31
    Post-IP 1.23 ± 0.22 1.11 ± 0.25 1.28 ± 0.36 1.44 ± 0.26 1.07 ± 0.41 1.68 ± 0.24 1.21 ± 0.1 2.57 ± 0.39
    P-value <0.01 <0.01 0.22 0.44 0.7 0.82 0.04 0.71
Charge transfer, pC
    Pre-IP 1.00 ± 0.08 1.69 ± 0.24 1.16 ± 0.10 1.51 ± 0.19 1.20 ± 0.31 1.24 ± 0.17 1.15 ± 0.08 1.49 ± 0.30
    Post-IP 0.81 ± 0.09 1.28 ± 0.25 0.89 ± 0.09 1.10 ± 0.14 1.12 ± 0.22 1.28 ± 0.18 0.77 ± 0.02 1.40 ± 0.26
    P-value <0.01 <0.01 <0.01 <0.01 0.48 0.81 0.03 0.30
Time-to-peak, ms
    Pre-IP 2.01 ± 0.16 2.12 ± 0.21 2.38 ± 0.20 2.56 ± 0.21 2.63 ± 0.41 1.80 ± 0.10 2.08 ± 0.13 1.47 ± 0.22
    Post-IP 1.78 ± 0.14 2.09 ± 0.14 2.53 ± 0.27 2.37 ± 0.30 2.68 ± 0.55 1.78 ± 0.08 1.77 ± 0.43 1.49 ± 0.23
    P-value 0.15 0.90 0.2 0.54 0.76 0.1 0.41 0.92
Decaytime constant, ms
    Pre-IP 2.95 ± 0.21 2.85 ± 0.22 2.87 ± 0.30 3.26 ± 0.28 2.98 ± 0.74 2.51 ± 0.40 2.66 ± 0.16 2.55 ± 0.20
    Post-IP 3.25 ± 0.21 3.01 ± 0.31 2.96 ± 0.30 3.82 ± 0.35 3.03 ± 0.59 2.55 ± 0.37 2.94 ± 0.73 2.43 ± 0.25
    P-value 0.08 0.50 0.54 0.26 0.21 0.74 0.25 0.18

  • PPR, paired pulse ratio.

  • Data are expressed as mean ± SE. Pre-IP means the baseline activity starting 10 min before start IP. Post-IP means the activity 25–35 min after IP. P values for statistical significance have been obtained by applying paired t-tests between values of the same parameter pre- vs. post-IP.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Cerebellum Golgi cell cell capacitance (pF) 131.0 ± 13.0 (19) 131.0 (pF) Data Table
Cerebellum Golgi cell input resistance (Mohm) 271.0 ± 37.0 (19) 271.0 (MΩ) Data Table