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Article: Repeated cocaine administration suppresses HVA-Ca2+ potentials and enhances activity of K+ channels in rat nucleus accumbens neurons.

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Hu XT; Basu S; White FJ
J. Neurophysiol., 2004



TABLE 1.Repeated cocaine administration in vivo altered the membrane properties and characteristics of HVA-Ca2+ potentials recorded in vitro
Group Saline pretreated (cells/rats) Cocaine pretreated (cells/rats)
TTX + 4-AP n = 8/8 n = 11/9
Passive membrane properties
    RMP, mV –79.0 ± 1.0 –84.0 ± 1.0**
        Rin, mΩ 47.6 ± 5.6 41.5 ± 2.5
        τm, ms 6.5 ± 1.0 4.3 ± 1.6
    Active membrane properties
        Rheobase, nA 0.9 ± 0.2 1.7 ± 0.3*
        Threshold, mV –39.3 ± 2.9 –32.4 ± 2.6
        Amplitude of slow Ca2+ spike, mV 24.3 ± 3.7 19.5 ± 2.5
        Duration of slow Ca2+ spike, ms 8.4 ± 1.2 6.1 ± 0.7
        AHP of slow Ca2+ spike, mV 22.3 ± 2.6 34.6 ± 3.2*
        Ca2+ Spike evoked in neurons, % 100 (8/8) 45.5 (5/11)*
TEA n = 12/10 n = 10/8
    Passive membrane properties
        RMP, mV –76.0 ± 1.1 –83.0 ± 1.4**
        Rin, mΩ N/A + N/A +
        τm, ms N/A + N/A +
    Active membrane properties
        Rheobase, nA 0.6 ± 0.1 1.0 ± 0.2*
        Threshold, mV N/A ++ N/A ++
        Amplitude of Ca2+ plateau potential, ms N/A ++ N/A ++
        Duration at 1/2 amplitude, ms 145.7 ± 24.7 55.5 ± 11.8**
        Secondary Ca2+ potential, % of cells 100% (12/12) 40% (4/10)#
TTX + TEA + Csin n = 16/8 n = 15/7
    Passive membrane properties
        RMP, mV –68.7 ± 1.2 –70.1 ± 0.7
        Rin, mΩ N/A + N/A +
        τm, ms N/A + N/A +
    Active membrane properties
        Rheobase, nA 0.9 ± 0.1 1.2 ± 0.1*
        Threshold, mV –14.2 ± 1.3 –11.6 ± 1.5
        Amplitude of Ca2+ plateau potential, ms 58.2 ± 1.8 54.5 ± 1.6
        Duration at 1/2 amplitude, ms 315.4 ± 24.3 210.1 ± 16.3**
    Total area of plateau potential, mV x ms 38,016 ± 2,889 25,502 ± 2,042**
+: Not available due to the use of short duration of current pulse (20 ms) ++: Not available due to difficulty in measuring the threshold with TEA but without TTX. Values are means ± SE. 4-AP, 4-aminopyridine; RMP, resting membrane potential; Rin, input resistance; Tm, time constant.

* P < 0.05,

** P < 0.01, t-test,

# P < 0.05, χ2 test.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Nucleus accumbens medium spiny neuron spike amplitude (ms) 58.2 ± 1.8 58.2 (mV) Data Table
Nucleus accumbens medium spiny neuron spike half-width (ms) 315.4 ± 24.3 0.3154 (ms) Data Table
Nucleus accumbens medium spiny neuron resting membrane potential (mV) -79.0 ± 1.0 -79.0 (mV) Data Table
Nucleus accumbens medium spiny neuron input resistance (mΩ) 47.6 ± 5.6 47.6 (MΩ) Data Table
Nucleus accumbens medium spiny neuron membrane time constant (ms) 6.5 ± 1.0 6.5 (ms) Data Table
Nucleus accumbens medium spiny neuron rheobase (nA) 0.9 ± 0.2 900.0 (pA) Data Table
Nucleus accumbens medium spiny neuron spike threshold (mV) -39.3 ± 2.9 -39.3 (mV) Data Table
Nucleus accumbens medium spiny neuron spike amplitude (mV) 24.3 ± 3.7 24.3 (mV) Data Table
Nucleus accumbens medium spiny neuron spike half-width (ms) 8.4 ± 1.2 8.4 (ms) Data Table
Nucleus accumbens medium spiny neuron AHP amplitude (mV) 22.3 ± 2.6 22.3 (mV) Data Table
Nucleus accumbens medium spiny neuron resting membrane potential (mV) -76.0 ± 1.1 -76.0 (mV) Data Table
Nucleus accumbens medium spiny neuron rheobase (nA) 0.6 ± 0.1 600.0 (pA) Data Table
Nucleus accumbens medium spiny neuron spike half-width (ms) 145.7 ± 24.7 0.1457 (ms) Data Table
Nucleus accumbens medium spiny neuron resting membrane potential (mV) -68.7 ± 1.2 -68.7 (mV) Data Table
Nucleus accumbens medium spiny neuron rheobase (nA) 0.9 ± 0.1 900.0 (pA) Data Table
Nucleus accumbens medium spiny neuron spike threshold (mV) -14.2 ± 1.3 -14.2 (mV) Data Table