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Article: GCP II (NAALADase) inhibition suppresses mossy fiber-CA3 synaptic neurotransmission by a presynaptic mechanism.

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Sanabria ER; Wozniak KM; Slusher BS; Keller A
J. Neurophysiol., 2004



TABLE 1.Effect of GCP II inhibition on intrinsic membrane properties
Properties
Control
2-MPPA
P
Vm, mV -64.2 ± 1.9 -64.7 ± 1.7 0.59
Rm, MΩ 223.8 ± 7.1 230.5 ± 8.7 0.64
τm, ms 45.8 ± 7.1 49.9 ± 8.7 0.25
AP threshold, mV -42.4 ± 3.1 -41.2 ± 3.0 0.24
Rheobase, pA 98.9 ± 1.8 98.1 ± 2.0 0.15
AP amplitude, mV 105.7 ± 5.3 106.9 ± 5.6 0.65
ADP, mV 3.3 ± 0.9 3.4 ± 1.0 0.82
fAHP, mV
4.5 ± 0.5
4.9 ± 0.6
0.52
Recordings from CA3 pyramidal cells (n = 7) before (control) and after application of the glutamate carboxypeptidase II (GCP II) inhibitor, 2-(3-mercaptopropyl)-pentanedioic acid (2-MPPA). Values are expressed as means ± SE. Vm, resting membrane potential; Rm, input resistance; τm, membrane time constant; AP, action potential; ADP, afterdepolarization; fAHP, fast afterhyperpolarizing potential. Statistical comparisons performed by unpaired Student's t-test, P as indicated.

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA3 pyramidal cell input resistance (MΩ) 223.8 ± 7.1 (7) 223.8 (MΩ) Data Table
Hippocampus CA3 pyramidal cell membrane time constant (ms) 45.8 ± 7.1 (7) 45.8 (ms) Data Table
Hippocampus CA3 pyramidal cell spike threshold (mV) -42.4 ± 3.1 (7) -42.4 (mV) Data Table
Hippocampus CA3 pyramidal cell rheobase (pA) 98.9 ± 1.8 (7) 98.9 (pA) Data Table
Hippocampus CA3 pyramidal cell spike amplitude from resting (mV) 105.7 ± 5.3 (7) 105.7 (mV) Data Table
Hippocampus CA3 pyramidal cell ADP amplitude (mV) 3.3 ± 0.9 (7) 3.3 (mV) Data Table
Hippocampus CA3 pyramidal cell fast AHP amplitude 4.5 ± 0.5 (7) 4.5 (mV) Data Table
Hippocampus CA3 pyramidal cell resting membrane potential (mV) -64.2 ± 1.9 (7) -64.2 (mV) Data Table