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Article: Persistent Nav1.6 current at axon initial segments tunes spike timing of cerebellar granule cells.

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Osorio N; Cathala L; Meisler MH; Crest M; Magistretti J; Delmas P
J. Physiol. (Lond.), 2010


Table 1. INaP activation parameters

Time point: 3.5–7.5 min Time point: 10–14.5 min
WT Scn8a KO P WT Scn8a KO P
mean ± s.d. n mean ± s.d. n mean ± s.d. n mean ± s.d. n
The table shows INaP activation parameters (V1/2 and k, in mV) returned by Boltzmann fittings of PNaP(V) plots. Statistical comparisons were made applying Student's two-tail t test for unpaired data.
0.1 V s−1
V1/2 −55.9 ± 3.4 15 −56.0 ± 4.5 6 0.96 −59.7 ± 2.8 15 −60.6 ± 3.9 6 0.59
k  −3.6 ± 0.7  −3.0 ± 0.4 0.08  −3.5 ± 0.6  −3.0 ± 0.6 0.15
0.05 V s−1
V1/2 −56.7 ± 2.7 15 −56.5 ± 3.2 6 0.87 −59.7 ± 2.8 15 −60.7 ± 3.2 6 0.49
k  −3.9 ± 0.8  −3.5 ± 0.9 0.33  −3.9 ± 1.1  −3.1 ± 0.6 0.11

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