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Article: Differential effects of Na+-K+ ATPase blockade on cortical layer V neurons.

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Anderson TR; Huguenard JR; Prince DA
J. Physiol. (Lond.), 2010


Table 1. Intrinsic membrane properties of different groups of recorded neurons

PYR1 (n = 9) PYR2 (n = 10) FS (n = 8)
Values ± x are means ± s.e.m. Ih, membrane potential sag, reflective of hyperpolarization-activated cation current; AHP, afterhyperpolarization potential; RS, regular spiking; IB, intrinsically bursting; f–I, frequency–current. Firing properties were calculated for the first depolarizing step (in 50 pA increments) that reliably produced action potentials (100 pA for PYR, 250 pA for FS).The f–I slope and adaptation index were calculated as described in the Methods. †P < 0.05 statistically different from PYR1. *P < 0.05 statistically different from PYR2.
DHO – membrane depolarization (mV) 10.0 ± 0.4* 2.7 ± 0.3 5.2 ± 0.8†*
Resting membrane potential (mV) −64.1 ± 0.9 −62.0 ± 1.3 −67.4 ± 1.5*
Input resistance (MΩ)
 Control 119.7 ± 19.5 116.6 ± 15.8 80.9 ± 8.5†*
 DHO 127.6 ± 20.5 129.8 ± 16.4 79.3 ± 8.4†*
Capacitance (pF) 125.5 ± 22.3 116.9 ± 13.5 38.2 ± 5.3†*
Ih (mV) 4.30 ± 0.8 4.35 ± 0.8 1.17 ± 0.3†*
Post-train AHP (mV) 4.32 ± 0.8 3.72 ± 0.7 0.95 ± 0.1†*
Firing properties
 Type (RS/IB) 8/1 8/2
 Mean firing frequency (Hz) 14.8 ± 2.6 14.1 ± 3.0 73.4 ± 35.3†*
fI slope 7.4 ± 0.2 7.0 ± 0.4 120.8 ± 14.3†*
 Adaptation index 18.5 ± 3.1 20.3 ± 4.8 9.1 ± 5.9
Mean age (postnatal days) 19.8 ± 3.0 17.8 ± 1.0 21.0 ± 0.9
 (range) (17–27) (16–27) (18–27)

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory cortex large amplitude pyramidal cells input resistance 119.7 ± 19.5 (9) 119.7 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory cortex small amplitude pyramidal cells input resistance 116.6 ± 15.8 (10) 116.6 (MΩ) Data Table
Neocortex basket cell Layer 5 somatosensory cortex Fast Spiking parvalbumin positive interneurons input resistance 80.9 ± 8.5 (8) 80.9 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory cortex large amplitude pyramidal cells cell capacitance (pF) 125.5 ± 22.3 (9) 125.5 (pF) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory cortex small amplitude pyramidal cells cell capacitance (pF) 116.9 ± 13.5 (10) 116.9 (pF) Data Table
Neocortex basket cell Layer 5 somatosensory cortex Fast Spiking parvalbumin positive interneurons cell capacitance (pF) 38.2 ± 5.3 (8) 38.2 (pF) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory cortex large amplitude pyramidal cells sag amplitude (mV) 4.3 ± 0.8 (9) 4.3 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory cortex small amplitude pyramidal cells sag amplitude (mV) 4.35 ± 0.8 (10) 4.35 (mV) Data Table
Neocortex basket cell Layer 5 somatosensory cortex Fast Spiking parvalbumin positive interneurons sag amplitude (mV) 1.17 ± 0.3 (8) 1.17 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory cortex large amplitude pyramidal cells medium AHP amplitude (mV) 4.32 ± 0.8 (9) 4.32 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory cortex small amplitude pyramidal cells medium AHP amplitude (mV) 3.72 ± 0.7 (10) 3.72 (mV) Data Table
Neocortex basket cell Layer 5 somatosensory cortex Fast Spiking parvalbumin positive interneurons medium AHP amplitude (mV) 0.95 ± 0.1 (8) 0.95 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory cortex large amplitude pyramidal cells firing frequency (Hz) 14.8 ± 2.6 (9) 14.8 (Hz) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory cortex small amplitude pyramidal cells firing frequency (Hz) 14.1 ± 3.0 (10) 14.1 (Hz) Data Table
Neocortex basket cell Layer 5 somatosensory cortex Fast Spiking parvalbumin positive interneurons firing frequency (Hz) 73.4 ± 35.3 (8) 73.4 (Hz) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory cortex large amplitude pyramidal cells FI slope 7.4 ± 0.2 (9) 7.4 (Hz/nA) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory cortex small amplitude pyramidal cells FI slope 7.0 ± 0.4 (10) 7.0 (Hz/nA) Data Table
Neocortex basket cell Layer 5 somatosensory cortex Fast Spiking parvalbumin positive interneurons FI slope 120.8 ± 14.3 (8) 120.8 (Hz/nA) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory cortex large amplitude pyramidal cells adaptation percent (1 – first/last ISI) 18.5 ± 3.1 (9) 18.5 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory cortex small amplitude pyramidal cells adaptation percent (1 – first/last ISI) 20.3 ± 4.8 (10) 20.3 (ratio) Data Table
Neocortex basket cell Layer 5 somatosensory cortex Fast Spiking parvalbumin positive interneurons adaptation percent (1 – first/last ISI) 9.1 ± 5.9 (8) 9.1 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory cortex large amplitude pyramidal cells resting membrane potential (mV) -64.1 ± 0.9 (9) -64.1 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory cortex small amplitude pyramidal cells resting membrane potential (mV) -62.0 ± 1.3 (10) -62.0 (mV) Data Table
Neocortex basket cell Layer 5 somatosensory cortex Fast Spiking parvalbumin positive interneurons resting membrane potential (mV) -67.4 ± 1.5 (8) -67.4 (mV) Data Table