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Article: Hindlimb unweighting for 2 weeks alters physiological properties of rat hindlimb motoneurones.

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Cormery B; Beaumont E; Csukly K; Gardiner P
J. Physiol. (Lond.), 2005


Table 1. Motoneurone passive and threshold properties

Property Weight-bearing Unweighted Difference
Fast Slow Fast Slow
Data are presented as means ± 1 s.d. Two-way ANOVA was used for analysis. In right-hand column, A indicates type (slow versus fast) of significant main effect only (P < 0.01) and B indicates both group (weight-bearing versus unweighted) and type (fast versus slow) significant main effects (P < 0.02), with difference due to group effect shown in bold, and C indicates a significant interaction effect (P < 0.02), with mean which is different from all others shown in bold.
Rheobase (nA) 8.0 ± 4.7 (88) 6.0 ± 3.8 (60) 10.6 ± 4.3(52) 6.4 ± 4.2 (23) B
Input resistance (MΩ) 1.7 ± 1.5 (55) 2.7 ± 1.4 (51)  1.7 ± 1.3 (45) 2.6 ± 1.3 (20) A
Spike amplitude (mV)   77 ± 12.3 (91)   84 ± 12.1 (58)    73 ± 12.0 (51)   74 ± 11.5 (24) B
Rheobasic spike amplitude (mV)  58 ± 7.5 (89)  64 ± 7.7 (60)   52 ± 7.8 (51) 55 ± 7.2 (19) B
RMP (mV) −61 ± 7.4 (87)  −63 ± 7.5 (57)  −59 ± 7.5 (48) −63 ± 7.7 (24) 
AHP half-decay time (ms) 14.4 ± 3.8 (93)  28.6 ± 3.9 (61)  14.6 ± 4.3 (52) 27.0 ± 3.8 (24)  A
AHP amplitude (mV) 1.5 ± 0.9 (80) 2.9 ± 0.7 (57) 1.3 ± 0.7 (52) 2.0 ± 1.0 (24) B
Spike threshold (mV) −43 ± 9.1 (83)  −42 ± 8.8 (55)  −38 ± 9.3 (46) −45 ± 8.9 (19)  C
Time constant (ms) 4.5 ± 1.3 (53) 5.4 ± 1.9 (46) 4.0 ± 0.9 (47) 4.4 ± 0.9 (22) B
Cell capacitance (nF) 3.5 ± 1.8 (30) 2.8 ± 1.8(34)  2.8 ± 1.5 (38) 2.1 ± 1.2 (20) B

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Spinal cord ventral horn motor neuron alpha input resistance (MΩ) 1.7 ± 1.3 (45) 1700.0 (MΩ) Data Table
Spinal cord ventral horn motor neuron alpha spike amplitude (mV) 73.0 ± 12.0 (51) 73.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha resting membrane potential (mV) -59.0 ± 7.5 (48) -59.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha AHP amplitude (mV) 1.3 ± 0.7 (52) 1.3 (mV) Data Table
Spinal cord ventral horn motor neuron alpha spike threshold (mV) -38.0 ± 9.3 (46) -38.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha rheobase (nA) 10.6 ± 4.3 (52) -- Data Table
Spinal cord ventral horn motor neuron alpha membrane time constant (ms) 4.0 ± 0.9 (47) 4.0 (ms) Data Table
Spinal cord ventral horn motor neuron alpha cell capacitance (nF) 2.8 ± 1.5 (38) 2800.0 (pF) Data Table