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Article: Calcium and calcium-activated currents in vagotomized rat primary vagal afferent neurons.

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Lancaster E; Oh EJ; Gover T; Weinreich D
J. Physiol. (Lond.), 2002


Table 1

Electrophysiological membrane properties of DAP(+) and DAP(−) vagotomized NGNs

Vagotomized NGNs
Parameter Control NGNs (n = 36) DAP(+) (n = 46) DAP(−) (n = 36)
Em (mV) −46 ± 1 −51 ± 1* −52 ± 1*
Cm (pF) 37 ± 2 46 ± 2*† 40 ± 2
Rin (MΩ) 389 ± 34 412 ± 30 † 300 ± 26
AP overshoot (mV) 51 ± 2 46 ± 2 50 ± 2
AP peak hyperpolarization (mV) −70 ± 0 −66 ± 3* −68 ± 0*
AP duration (ms) 1.6 ± 0.2 1.4 ± 0.1 1.5 ± 0.1
Rheobase (pA) 108 ± 23 193 ± 18* 289 ± 26*
1 × threshold (#APs) 2 ± 1 2 ± 1* 1 ± 0*
2 × threshold (#APs) 6 ± 1 3 ± 1* 2 ± 0*
3 × threshold (#APs) 7 ± 1 3 ± 2* 3 ± 0*
0.1–0.9 nA (#APs) 15 ± 3 4 ± 2* 3 ± 1*

  • Em (mV), membrane potential; Rin (MΩ), membrane input resistance; Cm (pF), membrane capacitance; AP overshoot (mV), most positive membrane potential during a single evoked AP; AP peak hyperpolarization (mV), most negative membrane potential during at single evoked AP; AP duration (ms), AP width at 0 mV; rheobase, minimum 750 ms current required to induce an AP; 1 × threshold (#APs), number of APs evoked by a 750 ms 1 × threshold depolarizing current; 2 × threshold (#APs), number of APs evoked by a 750 ms 2 × threshold depolarizing current; 3 × threshold (#APs), number of APs evoked by a 750 ms 3 × threshold depolarizing current; 0.1–0.9 nA (#APs), maximum number of APs evoked by a single 750 ms of magnitude 100–900 pA. Values are means ±s.e.m.

  • ↵* Significantly different from control.

  • ↵† Denotes significantly different from DAP(−) vagotomized NGNs.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dorsal root ganglion cell input resistance (MΩ) 389.0 ± 34.0 (36) 389.0 (MΩ) Data Table
Dorsal root ganglion cell spike peak (mV) -70.0 (36) -- Data Table
Dorsal root ganglion cell resting membrane potential (mV) -46.0 ± 1.0 (36) -46.0 (mV) Data Table
Dorsal root ganglion cell spike width (ms) 1.6 ± 0.2 (36) 1.6 (ms) Data Table
Dorsal root ganglion cell rheobase (pA) 108.0 ± 23.0 (36) 108.0 (pA) Data Table
Dorsal root ganglion cell cell capacitance (pF) 37.0 ± 2.0 (36) 37.0 (pF) Data Table