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Article: Hyperexcitability and reduced low threshold potassium currents in auditory neurons of mice lacking the channel subunit Kv1.1.

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Brew HM; Hallows JL; Tempel BL
J. Physiol. (Lond.), 2003


Table 1

Excitability parameters in Kcna+/+, −/− and +/− MNTB neurons

+/+(n = 29) +/−(n = 13) −/−(n = 20)
Number of APs at 200 pA 5.3 ± 1.1 5.0 ± 1.6†† 10.8 ± 1.8**
1. Threshold current (pA) 90 ± 6 95 ± 11†† 48 ± 6**
2. Threshold current for 2 APs (pA) 131 ± 8a 138 ± 15b†† 77 ± 9**
Difference between 1 and 2 (pA) 50 ± 4a 48 ± 11b 28 ± 4**
Resting potential (mV) 65.9 ± 0.9 −67.1 ± 2.0 −64.7 ± 1.1
Steady response at 100 pA (mV) −54.5 ± 0.7c −54.8 ± 1.5 −51.6 ± 0.7d**
Input resistance (Ω) 169 ± 11 194 ± 22 242 ± 30*
Features of 1st AP at 200 pA
Peak amplitude (mV) 24.5 ± 1.6 21.1 ± 2.5 22.2 ± 2.5
Afterhyperpolarization (mV) −81.9 ± 1.5 −82.6 ± 3.5 −78.2 ± 1.5
Inflexion potential (mV) −46.5 ± 0.6 −46.4 ± 1.7 −46.8 ± 0.9
Half-width (ms) 0.90 ± 0.03 0.84 ± 0.07†† 1.01 ± 0.04*
Latency (ms) 4.2 ± 0.3 4.1 ± 0.6 3.6 ± 0.4
Latency of threshold AP (ms) 8.6 ± 0.5 8.1 ± 0.8 14.0 ± 3.5
Time of final AP at 200 pA (ms) 44 ± 11 37 ± 14†† 89 ± 15**
Interspike interval at 200 pA (ms) 9.0 ± 0.6a 8.1 ± 0.4b 9.6 ± 0.6
  • All values are mean±s.E.M. for the same number of neurons as in Figs 1C and 5 except where indicated by superscripts a–d, either because some neurons fired only single APs (a = 25, b = 12) or because the presence of APs meant the membrane potential did not achieve a steady-state (c = 28, d = 17). Statistical tests were two-tailed unpaired Student's t tests, or Mann-Whitney U tests for measures of AP timing and numbers (first row and last 4 rows). significantly different from +/+ values. significantly different from −/− values. Parameter measurements are described below, except AP numbers and threshold currents (see Methods) and steady-state membrane potential responses (see Fig. ID legend). Resting potential was taken as the steady-state potential during the 0 pA ‘step’. Input resistance was measured using the difference in the steady-state responses to 0 and 20 pA steps. Features of the initial AP at 200 pA: peak and afterhyperpolarization amplitudes were determined using 5 data point sliding averages; inflexion potential was the sampled potential just before the depolarization rate exceeded 20 mV ms−1; half- width was measured halfway between rest and the peak. Initial AP latencies were measured using the time of the maximum depolarization rate. For final AP times and interspike intervals, AP times were detected using a cursor at −27 mV. The average interspike interval at 200 pA was calculated for each neuron before averaging across neurons.

  • †† P< 0.005;

  • ** P< 0.005;

  • P< 0.05 and

  • * P <0.05


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Medial Nucleus of Trapezoid Body neuron resting membrane potential (mV) 65.9 ± 0.9 (29) -65.9 (mV) Data Table
Medial Nucleus of Trapezoid Body neuron input resistance (Ω) 169.0 ± 11.0 (29) -- Data Table
Medial Nucleus of Trapezoid Body neuron spike peak (mV) 24.5 ± 1.6 (29) 24.5 (mV) Data Table
Medial Nucleus of Trapezoid Body neuron AHP voltage (mV) -81.9 ± 1.5 (29) -81.9 (mV) Data Table
Medial Nucleus of Trapezoid Body neuron spike threshold (mV) -46.5 ± 0.6 (29) -46.5 (mV) Data Table
Medial Nucleus of Trapezoid Body neuron spike half-width (ms) 0.9 ± 0.03 (29) 0.9 (ms) Data Table
Medial Nucleus of Trapezoid Body neuron first spike latency (ms) 4.2 ± 0.3 (29) 4.2 (ms) Data Table
Medial Nucleus of Trapezoid Body neuron first spike latency (ms) 8.6 ± 0.5 (29) 8.6 (ms) Data Table
Medial Nucleus of Trapezoid Body neuron rheobase (pA) 90.0 ± 6.0 (29) 90.0 (pA) Data Table