AboutNeuron TypesElectrophysiology PropertiesArticlesFAQsData/APIGet Involved

Neocortex pyramidal cell layer 5-6 (Definition)

Electrophysiological properties of Neocortex pyramidal cell layer 5-6s from literature:

    Legend:
  • Reports: Blue dots indicate human-curated values; Orange dots indicate non-human curated values
  • Mean+SD: mean and standard deviation of human-curated neuron measurements
  • All neurons: mean and standard deviation computed over all neurons in database
  • Interactivity:
  • Mouse over neuron report data points and click to view corresponding publication
  • Mouse over y- axis labels to view definition or click to view values across neuron types
  • Zoom in on a section of plot by dragging cursor. Zoom out by double clicking on plot.
  • Legend: Blue dots = text-mined values human curated; Orange dots = text-mined values not human curated









































View data in table form

Articles with extracted electrophysiology properties:

Article Title Authors Journal Year Electrophys values Neuron types
Two populations of layer v pyramidal cells of the mouse neocortex: development and sensitivity to anesthetics. (NeuroElectro data) (PubMed) Christophe E; Doerflinger N; Lavery DJ; Molnár Z; Charpak S; Audinat E J. Neurophysiol. 2005 28 1
Environmental manipulations early in development alter seizure activity, Ih and HCN1 protein expression later in life. (NeuroElectro data) (PubMed) Schridde U; Strauss U; Bräuer AU; van Luijtelaar G Eur. J. Neurosci. 2006 5 1
Evidence of altered inhibition in layer V pyramidal neurons from neocortex of Kcna1-null mice. (NeuroElectro data) (PubMed) van Brederode JF; Rho JM; Cerne R; Tempel BL; Spain WJ Neuroscience 2001 6 1
Transgenic mice expressing a fluorescent in vivo label in a distinct subpopulation of neocortical layer 5 pyramidal cells. (NeuroElectro data) (PubMed) Akemann W; Zhong YM; Ichinohe N; Rockland KS; Knöpfel T J. Comp. Neurol. 2004 12 1
Mechanisms and consequences of action potential burst firing in rat neocortical pyramidal neurons. (NeuroElectro data) (PubMed) Williams SR; Stuart GJ J. Physiol. (Lond.) 1999 15 1
Properties of layer 6 pyramidal neuron apical dendrites. (NeuroElectro data) (PubMed) Ledergerber D; Larkum ME J. Neurosci. 2010 8 1
The GABAB1b isoform mediates long-lasting inhibition of dendritic Ca2+ spikes in layer 5 somatosensory pyramidal neurons. (NeuroElectro data) (PubMed) Pérez-Garci E; Gassmann M; Bettler B; Larkum ME Neuron 2006 4 1
Loss of sensory input increases the intrinsic excitability of layer 5 pyramidal neurons in rat barrel cortex. (NeuroElectro data) (PubMed) Breton JD; Stuart GJ J. Physiol. (Lond.) 2009 9 1
Effect of common anesthetics on dendritic properties in layer 5 neocortical pyramidal neurons. (NeuroElectro data) (PubMed) Potez S; Larkum ME J. Neurophysiol. 2008 9 1
Early exposure to alcohol leads to permanent impairment of dendritic excitability in neocortical pyramidal neurons. (NeuroElectro data) (PubMed) Granato A; Palmer LM; De Giorgio A; Tavian D; Larkum ME J. Neurosci. 2012 9 1
Neuromodulation by a cytokine: interferon-beta differentially augments neocortical neuronal activity and excitability. (NeuroElectro data) (PubMed) Hadjilambreva G; Mix E; Rolfs A; Müller J; Strauss U J. Neurophysiol. 2005 18 2
Anatomy, physiology, and synaptic responses of rat layer V auditory cortical cells and effects of intracellular GABA(A) blockade. (NeuroElectro data) (PubMed) Hefti BJ; Smith PH J. Neurophysiol. 2000 6 1
Laminar localization, morphology, and physiological properties of pyramidal neurons that have the low-threshold calcium current in the guinea-pig medial frontal cortex. (NeuroElectro data) (PubMed) de la Peña E; Geijo-Barrientos E J. Neurosci. 1996 8 2
GABAA receptor-mediated currents in interneurons and pyramidal cells of rat visual cortex. (NeuroElectro data) (PubMed) Xiang Z; Huguenard JR; Prince DA J. Physiol. (Lond.) 1998 14 3
Differential effects of Na+-K+ ATPase blockade on cortical layer V neurons. (NeuroElectro data) (PubMed) Anderson TR; Huguenard JR; Prince DA J. Physiol. (Lond.) 2010 24 2
Interlaminar differences of intrinsic properties of pyramidal neurons in the auditory cortex of mice. (NeuroElectro data) (PubMed) Huggenberger S; Vater M; Deisz RA Cereb. Cortex 2009 48 2
Repeated cocaine administration increases voltage-sensitive calcium currents in response to membrane depolarization in medial prefrontal cortex pyramidal neurons. (NeuroElectro data) (PubMed) Nasif FJ; Hu XT; White FJ J. Neurosci. 2005 4 1
Region-specific spike-frequency acceleration in layer 5 pyramidal neurons mediated by Kv1 subunits. (NeuroElectro data) (PubMed) Miller MN; Okaty BW; Nelson SB J. Neurosci. 2008 6 1
Action potential initiation and propagation in layer 5 pyramidal neurons of the rat prefrontal cortex: absence of dopamine modulation. (NeuroElectro data) (PubMed) Gulledge AT; Stuart GJ J. Neurosci. 2003 2 1
GABAergic synaptic inhibition is reduced before seizure onset in a genetic model of cortical malformation. (NeuroElectro data) (PubMed) Trotter SA; Kapur J; Anzivino MJ; Lee KS J. Neurosci. 2006 3 2
Glutamatergic nonpyramidal neurons from neocortical layer VI and their comparison with pyramidal and spiny stellate neurons. (NeuroElectro data) (PubMed) Andjelic S; Gallopin T; Cauli B; Hill EL; Roux L; Badr S; Hu E; Tamás G; Lambolez B J. Neurophysiol. 2009 30 4
Inter- and intralaminar subcircuits of excitatory and inhibitory neurons in layer 6a of the rat barrel cortex. (NeuroElectro data) (PubMed) Kumar P; Ohana O J. Neurophysiol. 2008 40 2
Layer V neurons in mouse cortex projecting to different targets have distinct physiological properties. (NeuroElectro data) (PubMed) Hattox AM; Nelson SB J. Neurophysiol. 2007 32 1
Early postnatal plasticity in neocortex of Fmr1 knockout mice. (NeuroElectro data) (PubMed) Desai NS; Casimiro TM; Gruber SM; Vanderklish PW J. Neurophysiol. 2006 6 1
Reduced excitatory drive in interneurons in an animal model of cortical dysplasia. (NeuroElectro data) (PubMed) Xiang H; Chen HX; Yu XX; King MA; Roper SN J. Neurophysiol. 2006 18 3
Metabotropic glutamate receptors are involved in long-term potentiation in isolated slices of rat medial frontal cortex. (NeuroElectro data) (PubMed) Vickery RM; Morris SH; Bindman LJ J. Neurophysiol. 1997 5 1
Epileptogenesis following neocortical trauma from two sources of disinhibition. (NeuroElectro data) (PubMed) Yang L; Benardo LS J. Neurophysiol. 1997 12 2
Specialized cortical subnetworks differentially connect frontal cortex to parahippocampal areas. (NeuroElectro data) (PubMed) Hirai Y; Morishima M; Karube F; Kawaguchi Y J. Neurosci. 2012 24 3
Local connections of excitatory neurons to corticothalamic neurons in the rat barrel cortex. (NeuroElectro data) (PubMed) Tanaka YR; Tanaka YH; Konno M; Fujiyama F; Sonomura T; Okamoto-Furuta K; Kameda H; Hioki H; Furuta T; Nakamura KC; Kaneko T J. Neurosci. 2011 48 3
Postnatal development of intrinsic and synaptic properties transforms signaling in the layer 5 excitatory neural network of the visual cortex. (NeuroElectro data) (PubMed) Etherington SJ; Williams SR J. Neurosci. 2011 18 1
Enhanced function of prefrontal serotonin 5-HT(2) receptors in a rat model of psychiatric vulnerability. (NeuroElectro data) (PubMed) Benekareddy M; Goodfellow NM; Lambe EK; Vaidya VA J. Neurosci. 2010 3 2
Maturation of "neocortex isole" in vivo in mice. (NeuroElectro data) (PubMed) Zhou L; Gall D; Qu Y; Prigogine C; Cheron G; Tissir F; Schiffmann SN; Goffinet AM J. Neurosci. 2010 17 2
M1 receptors mediate cholinergic modulation of excitability in neocortical pyramidal neurons. (NeuroElectro data) (PubMed) Gulledge AT; Bucci DJ; Zhang SS; Matsui M; Yeh HH J. Neurosci. 2009 6 2
Dopamine and corticotropin-releasing factor synergistically alter basolateral amygdala-to-medial prefrontal cortex synaptic transmission: functional switch after chronic cocaine administration. (NeuroElectro data) (PubMed) Orozco-Cabal L; Liu J; Pollandt S; Schmidt K; Shinnick-Gallagher P; Gallagher JP J. Neurosci. 2008 3 1
Deep layer somatosensory cortical neurons initiate spike-and-wave discharges in a genetic model of absence seizures. (NeuroElectro data) (PubMed) Polack PO; Guillemain I; Hu E; Deransart C; Depaulis A; Charpier S J. Neurosci. 2007 5 1
Developmental synaptic changes increase the range of integrative capabilities of an identified excitatory neocortical connection. (NeuroElectro data) (PubMed) Angulo MC; Staiger JF; Rossier J; Audinat E J. Neurosci. 1999 12 1
Postnatal development of synaptic transmission in local networks of L5A pyramidal neurons in rat somatosensory cortex. (NeuroElectro data) (PubMed) Frick A; Feldmeyer D; Sakmann B J. Physiol. (Lond.) 2007 3 1
Flexible spike timing of layer 5 neurons during dynamic beta oscillation shifts in rat prefrontal cortex. (NeuroElectro data) (PubMed) van Aerde KI; Mann EO; Canto CB; Heistek TS; Linkenkaer-Hansen K; Mulder AB; van der Roest M; Paulsen O; Brussaard AB; Mansvelder HD J. Physiol. (Lond.) 2009 24 3
Sub- and suprathreshold receptive field properties of pyramidal neurones in layers 5A and 5B of rat somatosensory barrel cortex. (NeuroElectro data) (PubMed) Manns ID; Sakmann B; Brecht M J. Physiol. (Lond.) 2004 9 2
Electrophysiological Abnormalities in Both Axotomized and Nonaxotomized Pyramidal Neurons following Mild Traumatic Brain Injury. (NeuroElectro data) (PubMed) Greer JE; Povlishock JT; Jacobs KM J. Neurosci. 2012 9 1
Molecular and physiological diversity of cortical nonpyramidal cells. (NeuroElectro data) (PubMed) Cauli B; Audinat E; Lambolez B; Angulo MC; Ropert N; Tsuzuki K; Hestrin S; Rossier J J. Neurosci. 1997 34 3
Identification of brain neurons expressing the dopamine D4 receptor gene using BAC transgenic mice. (NeuroElectro data) (PubMed) Noaín D; Avale ME; Wedemeyer C; Calvo D; Peper M; Rubinstein M Eur. J. Neurosci. 2006 10 1
Synaptic organization and input-specific short-term plasticity in anterior cingulate cortical neurons with intact thalamic inputs. (NeuroElectro data) (PubMed) Lee CM; Chang WC; Chang KB; Shyu BC Eur. J. Neurosci. 2007 35 3
Calcium imaging in single neurons from brain slices using bioluminescent reporters. (NeuroElectro data) (PubMed) Drobac E; Tricoire L; Chaffotte AF; Guiot E; Lambolez B J. Neurosci. Res. 2010 6 1
Widely integrative properties of layer 5 pyramidal cells support a role for processing of extralaminar synaptic inputs in rat neocortex. (NeuroElectro data) (PubMed) Telfeian AE; Connors BW Neurosci. Lett. 2003 16 2
Repeated cocaine administration alters the electrophysiological properties of prefrontal cortical neurons. (NeuroElectro data) (PubMed) Trantham H; Szumlinski KK; McFarland K; Kalivas PW; Lavin A Neuroscience 2002 5 1
Protein-kinase C-dependent phosphorylation inhibits the effect of the antiepileptic drug topiramate on the persistent fraction of sodium currents. (NeuroElectro data) (PubMed) Curia G; Aracri P; Sancini G; Mantegazza M; Avanzini G; Franceschetti S Neuroscience 2004 6 1
Altered intrinsic properties of neuronal subtypes in malformed epileptogenic cortex. (NeuroElectro data) (PubMed) George AL; Jacobs KM Brain Res. 2011 33 3
Sleep loss alters synaptic and intrinsic neuronal properties in mouse prefrontal cortex. (NeuroElectro data) (PubMed) Winters BD; Huang YH; Dong Y; Krueger JM Brain Res. 2011 7 1
The excitatory neuronal network of the C2 barrel column in mouse primary somatosensory cortex. (NeuroElectro data) (PubMed) Lefort S; Tomm C; Floyd Sarria JC; Petersen CC Neuron 2009 36 3
Modulation of neuronal excitability by serotonin-NMDA interactions in prefrontal cortex. (NeuroElectro data) (PubMed) Zhong P; Yuen EY; Yan Z Mol. Cell. Neurosci. 2008 8 1
Short-term sleep deprivation increases intrinsic excitability of prefrontal cortical neurons. (NeuroElectro data) (PubMed) Yan J; Li JC; Xie ML; Zhang D; Qi AP; Hu B; Huang W; Xia JX; Hu ZA Brain Res. 2011 6 1
Differential modulatory effects of norepinephrine on synaptically driven responses of layer V barrel field cortical neurons. (NeuroElectro data) (PubMed) Waterhouse BD; Mouradian R; Sessler FM; Lin RC Brain Res. 2000 18 1
Differential regulation of synaptic transmission by adrenergic agonists via protein kinase A and protein kinase C in layer V pyramidal neurons of rat cerebral cortex. (NeuroElectro data) (PubMed) Kobayashi M Neuroscience 2007 12 1
Diversity of layer 5 projection neurons in the mouse motor cortex. (NeuroElectro data) (PubMed) Oswald MJ; Tantirigama ML; Sonntag I; Hughes SM; Empson RM Front Cell Neurosci 2013 56 1
Highly differentiated cellular and circuit properties of infralimbic pyramidal neurons projecting to the periaqueductal gray and amygdala. (NeuroElectro data) (PubMed) Ferreira AN; Yousuf H; Dalton S; Sheets PL Front Cell Neurosci 2015 27 2
Activity-dependent serotonergic excitation of callosal projection neurons in the mouse prefrontal cortex. (NeuroElectro data) (PubMed) Stephens EK; Avesar D; Gulledge AT Front Neural Circuits 2014 15 1
Multiple layer 5 pyramidal cell subtypes relay cortical feedback from secondary to primary motor areas in rats. (NeuroElectro data) (PubMed) Ueta Y; Otsuka T; Morishima M; Ushimaru M; Kawaguchi Y Cereb. Cortex 2014 10 1
Dendritic Target Region-Specific Formation of Synapses Between Excitatory Layer 4 Neurons and Layer 6 Pyramidal Cells. (NeuroElectro data) (PubMed) Qi G; Feldmeyer D Cereb. Cortex 2015 6 1
Enhanced infragranular and supragranular synaptic input onto layer 5 pyramidal neurons in a rat model of cortical dysplasia. (NeuroElectro data) (PubMed) Brill J; Huguenard JR Cereb. Cortex 2010 14 2
Functional Local Input to Layer 5 Pyramidal Neurons in the Rat Visual Cortex. (NeuroElectro data) (PubMed) Zarrinpar A; Callaway EM Cereb. Cortex 2014 21 1
Differences in intrinsic properties and local network connectivity of identified layer 5 and layer 6 adult mouse auditory corticothalamic neurons support a dual corticothalamic projection hypothesis. (NeuroElectro data) (PubMed) Llano DA; Sherman SM Cereb. Cortex 2009 19 1
Morphological, electrophysiological, and synaptic properties of corticocallosal pyramidal cells in the neonatal rat neocortex. (NeuroElectro data) (PubMed) Le Bé JV; Silberberg G; Wang Y; Markram H Cereb. Cortex 2007 26 1
Serotonin induces EPSCs preferentially in layer V pyramidal neurons of the frontal cortex in the rat. (NeuroElectro data) (PubMed) Lambe EK; Goldman-Rakic PS; Aghajanian GK Cereb. Cortex 2000 12 2
Intrinsic electrophysiology of mouse corticospinal neurons: a class-specific triad of spike-related properties. (NeuroElectro data) (PubMed) Suter BA; Migliore M; Shepherd GM Cereb. Cortex 2013 60 1
Distinct Physiological Effects of Dopamine D4 Receptors on Prefrontal Cortical Pyramidal Neurons and Fast-Spiking Interneurons. (NeuroElectro data) (PubMed) Zhong P; Yan Z Cereb. Cortex 2014 12 2
Morphological and physiological characterization of pyramidal neuron subtypes in rat medial prefrontal cortex. (NeuroElectro data) (PubMed) van Aerde KI; Feldmeyer D Cereb. Cortex 2015 122 2
Morphology, electrophysiology and functional input connectivity of pyramidal neurons characterizes a genuine layer va in the primary somatosensory cortex. (NeuroElectro data) (PubMed) Schubert D; Kötter R; Luhmann HJ; Staiger JF Cereb. Cortex 2006 15 1
Functional integration of human neural precursor cells in mouse cortex. (NeuroElectro data) (PubMed) Zhou FW; Fortin JM; Chen HX; Martinez-Diaz H; Chang LJ; Reynolds BA; Roper SN PLoS ONE 2015 32 2
Cholinergic excitation in mouse primary vs. associative cortex: region-specific magnitude and receptor balance. (NeuroElectro data) (PubMed) Tian MK; Bailey CD; Lambe EK Eur. J. Neurosci. 2014 9 1
Potentially epileptogenic dysfunction of cortical NMDA- and GABA-mediated neurotransmission in Otx1-/- mice. (NeuroElectro data) (PubMed) Sancini G; Franceschetti S; Lavazza T; Panzica F; Cipelletti B; Frassoni C; Spreafico R; Acampora D; Avanzini G Eur. J. Neurosci. 2001 14 1
Morphological and electrophysiological characteristics of layer V neurons of the rat lateral entorhinal cortex. (NeuroElectro data) (PubMed) Hamam BN; Amaral DG; Alonso AA J. Comp. Neurol. 2002 24 1
Impaired action potential initiation in GABAergic interneurons causes hyperexcitable networks in an epileptic mouse model carrying a human Na(V)1.1 mutation. (NeuroElectro data) (PubMed) Hedrich UB; Liautard C; Kirschenbaum D; Pofahl M; Lavigne J; Liu Y; Theiss S; Slotta J; Escayg A; Dihné M; Beck H; Mantegazza M; Lerche H J. Neurosci. 2014 35 6
Contributions of diverse excitatory and inhibitory neurons to recurrent network activity in cerebral cortex. (NeuroElectro data) (PubMed) Neske GT; Patrick SL; Connors BW J. Neurosci. 2015 70 6
Development of GABA circuitry of fast-spiking basket interneurons in the medial prefrontal cortex of erbb4-mutant mice. (NeuroElectro data) (PubMed) Yang JM; Zhang J; Chen XJ; Geng HY; Ye M; Spitzer NC; Luo JH; Duan SM; Li XM J. Neurosci. 2013 19 2
Control over stress, but not stress per se increases prefrontal cortical pyramidal neuron excitability. (NeuroElectro data) (PubMed) Varela JA; Wang J; Christianson JP; Maier SF; Cooper DC J. Neurosci. 2012 5 1
Fear extinction induces mGluR5-mediated synaptic and intrinsic plasticity in infralimbic neurons. (NeuroElectro data) (PubMed) Sepulveda-Orengo MT; Lopez AV; Soler-Cedeño O; Porter JT J. Neurosci. 2013 4 1
Impaired Cholinergic Excitation of Prefrontal Attention Circuitry in the TgCRND8 Model of Alzheimer's Disease. (NeuroElectro data) (PubMed) Proulx É; Fraser P; McLaurin J; Lambe EK J. Neurosci. 2015 5 1
Trace Fear Conditioning Differentially Modulates Intrinsic Excitability of Medial Prefrontal Cortex-Basolateral Complex of Amygdala Projection Neurons in Infralimbic and Prelimbic Cortices. (NeuroElectro data) (PubMed) Song C; Ehlers VL; Moyer JR J. Neurosci. 2015 26 1
Selective suppression of excitatory synapses on GABAergic interneurons by norepinephrine in juvenile rat prefrontal cortical microcircuitry. (NeuroElectro data) (PubMed) Wang HX; Waterhouse BD; Gao WJ Neuroscience 2013 15 1
Stimulation of D1-type dopamine receptors enhances excitability in prefrontal cortical pyramidal neurons in a state-dependent manner. (NeuroElectro data) (PubMed) Lavin A; Grace AA Neuroscience 2001 6 1
Oxidative stress induced by cumene hydroperoxide evokes changes in neuronal excitability of rat motor cortex neurons. (NeuroElectro data) (PubMed) Pardillo-Díaz R; Carrascal L; Ayala A; Nunez-Abades P Neuroscience 2015 8 1
Effects of ethanol on rat somatosensory cortical neurons. (NeuroElectro data) (PubMed) Sessler FM; Hsu FC; Felder TN; Zhai J; Lin RC; Wieland SJ; Kosobud AE Brain Res. 1998 18 2
Three Types of Cortical Layer 5 Neurons That Differ in Brain-wide Connectivity and Function. (NeuroElectro data) (PubMed) Kim EJ; Juavinett AL; Kyubwa EM; Jacobs MW; Callaway EM Neuron 2015 33 1
Cell-type specific properties of pyramidal neurons in neocortex underlying a layout that is modifiable depending on the cortical area. (NeuroElectro data) (PubMed) Groh A; Meyer HS; Schmidt EF; Heintz N; Sakmann B; Krieger P Cereb. Cortex 2010 16 1
Electrophysiological properties of genetically identified subtypes of layer 5 neocortical pyramidal neurons: Ca²⁺ dependence and differential modulation by norepinephrine. (NeuroElectro data) (PubMed) Guan D; Armstrong WE; Foehring RC J. Neurophysiol. 2015 42 2
Amygdala inputs drive feedforward inhibition in the medial prefrontal cortex. (NeuroElectro data) (PubMed) Dilgen J; Tejeda HA; O'Donnell P J. Neurophysiol. 2013 12 1
Strychnine-sensitive glycine receptors on pyramidal neurons in layers II/III of the mouse prefrontal cortex are tonically activated. (NeuroElectro data) (PubMed) Salling MC; Harrison NL J. Neurophysiol. 2014 14 2
Local-Circuit Phenotypes of Layer 5 Neurons in Motor-Frontal Cortex of YFP-H Mice. (NeuroElectro data) (PubMed) Yu J; Anderson CT; Kiritani T; Sheets PL; Wokosin DL; Wood L; Shepherd GM Front Neural Circuits 2008 10 1
Area-specific development of distinct projection neuron subclasses is regulated by postnatal epigenetic modifications. (NeuroElectro data) (PubMed) Harb K; Magrinelli E; Nicolas CS; Lukianets N; Frangeul L; Pietri M; Sun T; Sandoz G; Grammont F; Jabaudon D; Studer M; Alfano C Elife 2016 45 1
Hyperactive somatostatin interneurons contribute to excitotoxicity in neurodegenerative disorders. (NeuroElectro data) (PubMed) Zhang W; Zhang L; Liang B; Schroeder D; Zhang ZW; Cox GA; Li Y; Lin DT Nat. Neurosci. 2016 3 1
Impaired excitability of somatostatin- and parvalbumin-expressing cortical interneurons in a mouse model of Dravet syndrome. (NeuroElectro data) (PubMed) Tai C; Abe Y; Westenbroek RE; Scheuer T; Catterall WA Proc. Natl. Acad. Sci. U.S.A. 2014 30 3

Expert curators for Neocortex pyramidal cell layer 5-6s:

No assigned expert curators:

Become a neuron curator (login required)

More information about Neocortex pyramidal cell layer 5-6s in other resources: