WT | Fmr1 KO | P Value | |
---|---|---|---|
n | 16 | 9 | |
Rm, MΩ | 398 ± 23 | 496 ± 54 | 0.067 |
Vm, mV | −54.5 ± 0.8 | −54.4 ± 1.4 | 0.91 |
Membrane constant, ms | 36.4 ± 3.7 | 38.6 ± 4.1 | 0.71 |
Cm, pF | 92.1 ± 8.4 | 80.8 ± 8.6 | 0.40 |
AP half-width, ms | 1.98 ± 0.13 | 2.25 ± 0.17 | 0.21 |
AP amplitude, mV | 64.0 ± 2.5 | 59.3 ± 2.4 | 0.23 |
AP time to peak, ms | 1.37 ± 0.02 | 1.28 ± 0.02 | 0.013* |
Threshold current, pA | 16.9 ± 2.4 | 18.9 ± 2.6 | 0.60 |
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Values are means ± SE for passive and active properties of layer II/III low-threshold-spiking interneurons from wild-type (WT) and Fmr1 knockout (KO) mice; n = no. of neurons. Rm, membrane resistance; Vm, resting membrane potential; Cm, membrane capacitance; AP, action potential.
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↵* P < 0.05.