Article: Protein-kinase C-dependent phosphorylation inhibits the effect of the antiepileptic drug topiramate on the persistent fraction of sodium currents.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Curia G; Aracri P; Sancini G; Mantegazza M; Avanzini G; Franceschetti S Neuroscience, 2004
Table 2Effect of OAG and TPM on membrane and firing parametersa
(*)P<0.05 (in comparison with values measured under control conditions).aRn=membrane input resistance; Tau=membrane time constant; Threshold stimulus=amplitude of the depolarising current pulse needed to reach the firing threshold.
n | AP slope (V/s) | AP amplitude (mV) | AP repolarisation (V/s) | Rn (MΩ) | Tau (ms) | Threshold stimulus (nA) | |
Control | 5 | 322.1±23.0 | 103.7±3.3 | 115.8±12.0 | 34.1±3.2 | 10.7±0.3 | 0.19±0.04 |
TPM | 306.3±22.2(*) | 99.0±3.4 | 110.0±12.7 | 32.9±2.0 | 11.9±0.9 | 0.23±0.4(*) | |
Washout | 313.2±24.1 | 105.3±2.1 | 118.8±7.5 | 31.6±2.3 | 11.4±1.0 | 0.19±0.4 | |
Control | 6 | 304.6±20.1 | 105.0±3.0 | 137.3±8.1 | 30.7±2.4 | 11.2±0.7 | 0.22±0.07 |
OAG | 301.3±14.8 | 104.3±1.7 | 134.0±11.6 | 31.0±0.9 | 11.1±0.6 | 0.17±0.03(*) | |
TPM+OAG | 292.0±9.7 | 101.6±3.5 | 132.2±6.6 | 26.1±3.6 | 11.2±1.0 | 0.19±0.04 | |
TPM washout | 4 | 295.±17.5 | 100.3±4.4 | 124.0±4.7 | 38.1±3.0 | 9.1±0.5 | 0.20±0.06 |