Article: Adenosine inhibits basal forebrain cholinergic and noncholinergic neurons in vitro.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Arrigoni E; Chamberlin NL; Saper CB; McCarley RW Neuroscience, 2006
Table 2Electrophysiological properties of cholinergic and noncholinergic MCPO/SI neurons
ChAT (+) neurons include both 192IgG-positive/ChAT-positive neurons and ChAT-positive neurons from uninjected animals. Values are presented as means±SEM (n, number of cells). Significant differences were determined by one-way ANOVA tests. Cross symbols denote statistically significant differences across all three groups:†for P<0.05;††for P<0.01. Asterisks denote statistically significant differences between I group and II group of ChAT (−) neurons: * for P<0.05;⁎⁎for P<0.01.
Property | ChAT (+) neurons (n=59) | ChAT (−) neurons | |
Group I (n=25) | Group II (n=14) | ||
Resting potential (mV) | −55.3±1.0(n=59) | −47.4±2.1(n=14) | −50.9±1.7(n=13) |
Input resistance (MΩ) | 352±18(n=59) | 369±29(n=25) | 735±123(n=14)†† |
Presence of spontaneous firing; rate (Hz) | 15%(n=53);1.5±0.2(n=8) | 79%(n=19);5.00±0.70(n=16)† | 50%(n=14);1.7±0.4(n=7) |
Spike half-width (ms) | 2.94±0.16(n=59) | 1.99±0.31(n=22)† | 3.17±0.40(n=13) |
AHP amplitude (mV) | −12.34±0.90(n=23)† | −6.30±1.10(n=8) | −7.30±0.83(n=13) |
AHP duration (ms) | 345±30(n=23) | 190±46(n=8)† | 313±32(n=13) |
Presence of accommodation | 100%(n=24) | 2 of 11 neurons | 4 of 6 neurons |
Depolarizing sag (mV) (Ih activation) | +0.96±0.28mV†(n=40) | +11.1±0.7mV†⁎⁎(n=25) | +3.6±0.4mV†(n=14) |
Percentage of neurons inhibited by AD | 83%(n=41) | 83%(n=12) | 1 of 9 neurons |
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|---|---|---|---|---|
Other | Magnocellular preoptic nucleus/substantia innominata adenosine inhibited noncholinergic neurons | resting membrane potential (mV) | -47.4 ± 2.1 (14) | -47.4 (mV) | Data Table |
Other | Magnocellular preoptic nucleus/substantia innominata adenosine non-inhibited noncholinergic neurons | resting membrane potential (mV) | -50.9 ± 1.7 (13) | -50.9 (mV) | Data Table |
Basalis nucleus cholinergic neuron | Magnocellular preoptic nucleus/substantia innominata cholinergic neurons | input resistance (MΩ) | 352.0 ± 18.0 (59) | 352.0 (MΩ) | Data Table |
Other | Magnocellular preoptic nucleus/substantia innominata adenosine inhibited noncholinergic neurons | input resistance (MΩ) | 369.0 ± 29.0 (25) | 369.0 (MΩ) | Data Table |
Other | Magnocellular preoptic nucleus/substantia innominata adenosine non-inhibited noncholinergic neurons | input resistance (MΩ) | 735.0 ± 123.0 (14) | 735.0 (MΩ) | Data Table |
Basalis nucleus cholinergic neuron | Magnocellular preoptic nucleus/substantia innominata cholinergic neurons | spike half-width (ms) | 2.94 ± 0.16 (59) | 2.94 (ms) | Data Table |
Other | Magnocellular preoptic nucleus/substantia innominata adenosine inhibited noncholinergic neurons | spike half-width (ms) | 1.99 ± 0.31 (22) | 1.99 (ms) | Data Table |
Other | Magnocellular preoptic nucleus/substantia innominata adenosine non-inhibited noncholinergic neurons | spike half-width (ms) | 3.17 ± 0.4 (13) | 3.17 (ms) | Data Table |
Basalis nucleus cholinergic neuron | Magnocellular preoptic nucleus/substantia innominata cholinergic neurons | AHP amplitude (mV) | -12.34 ± 0.9 (23) | 12.34 (mV) | Data Table |
Other | Magnocellular preoptic nucleus/substantia innominata adenosine inhibited noncholinergic neurons | AHP amplitude (mV) | -6.3 ± 1.1 (8) | 6.3 (mV) | Data Table |
Other | Magnocellular preoptic nucleus/substantia innominata adenosine non-inhibited noncholinergic neurons | AHP amplitude (mV) | -7.3 ± 0.83 (13) | 7.3 (mV) | Data Table |
Basalis nucleus cholinergic neuron | Magnocellular preoptic nucleus/substantia innominata cholinergic neurons | AHP duration (ms) | 345.0 ± 30.0 (23) | 345.0 (ms) | Data Table |
Other | Magnocellular preoptic nucleus/substantia innominata adenosine inhibited noncholinergic neurons | AHP duration (ms) | 190.0 ± 46.0 (8) | 190.0 (ms) | Data Table |
Other | Magnocellular preoptic nucleus/substantia innominata adenosine non-inhibited noncholinergic neurons | AHP duration (ms) | 313.0 ± 32.0 (13) | 313.0 (ms) | Data Table |
Basalis nucleus cholinergic neuron | Magnocellular preoptic nucleus/substantia innominata cholinergic neurons | sag amplitude | 0.96 ± 0.28 (40) | 0.96 (mV) | Data Table |
Other | Magnocellular preoptic nucleus/substantia innominata adenosine inhibited noncholinergic neurons | sag amplitude | 11.1 ± 0.7 (25) | 11.1 (mV) | Data Table |
Other | Magnocellular preoptic nucleus/substantia innominata adenosine non-inhibited noncholinergic neurons | sag amplitude | 3.6 ± 0.4 (14) | 3.6 (mV) | Data Table |
Basalis nucleus cholinergic neuron | Magnocellular preoptic nucleus/substantia innominata cholinergic neurons | resting membrane potential (mV) | -55.3 ± 1.0 (59) | -55.3 (mV) | Data Table |