Article: Sleep fragmentation reduces hippocampal CA1 pyramidal cell excitability and response to adenosine.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Tartar JL; McKenna JT; Ward CP; McCarley RW; Strecker RE; Brown RE Neurosci. Lett., 2010
Table 1Passive and active postsynaptic membrane properties of CA1 pyramidal neurons in the 3 different experimental groups.
Abbreviations: AD=adenosine, AP=action potential, AHP=afterhyperpolarization, RMP=resting membrane potential, Rin=input resistance, sAHP=slow afterhyperpolarization.*Significant difference from cage control (p<0.05).**Significant difference from cage control (p<0.001).†Significant difference from exercise control (p<0.05).
Cage control (n=10) Mean±SEM | Exercise control (n=7) Mean±SEM | Sleep fragmentation (n=9) Mean±SEM | |
Property | |||
RMP (mV) | −70.1±1.3 | −68.5±1.9 | −68.9±0.6 |
Rin (MΩ) | 107±13.7 | 110±11.1 | 69.0±6.5*,† |
Membrane time constant (ms) | 17.3±1.4 | 15.3±0.7 | 14.2±1.3 |
% sag (largest hyperpolarizing step) | 15.4±1.8 | 10.8±1.8 | 8.2±5.4 |
AP threshold (mV) | −55.1±0.8 | −53.9±0.9 | −54.3±1.5 |
AP amplitude (mV) | 79.4±3.9 | 70.2±3.1 | 75.7±3.8 |
AP width (ms) | 1.6±0.2 | 2.0±0.1 | 1.6±0.1 |
AHP (mV) | −9.0±1.2 | −4.6±1.2* | −8.3±1.1 |
sAHP (mV) | −7.3±0.7 | −6.2±0.5 | −6.8±0.8 |
Initial firing frequency (Hz) | 16.6±1.9 | 13.6±4.2 | 14.6±1.8 |
Max firing frequency (Hz) | 42.8±6.2 | 39.3±6.2 | 40.2±3.8 |
Property before and during AD (30μM) application | |||
RMP pre-AD (mV) | −69.7±1.9 | −66.4±1.5 | −68.8±0.5 |
RMP post-AD (mV) | −74.9±1.8 | −70.1±1.5 | −71.6±0.7 |
AD hyperpolarization (mV) | −5.2±0.4 | −3.6±0.2* | −2.9±0.3** |