Article: Impaired firing properties of dentate granule neurons in an Alzheimer's disease animal model are rescued by PPARγ agonism.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Nenov MN; Tempia F; Denner L; Dineley KT; Laezza F J. Neurophysiol., 2015
Wild-type (n = 8) | Tg2576 (n = 13) | Tg2576 + RSG (n = 11) | P | |
---|---|---|---|---|
First peak latency, ms | 265.3 ± 17.4 | 303.2 ± 26.8 | 296.5 ± 36 | 0.7 |
Itrh, pA | 41.3 ± 5.5 | 36.9 ± 4.3 | 41.8 ± 2.9 | 0.6 |
Vtrh, mV | -45.2 ± 2.7 | -43.9 ± 1.9 | -43 ± 1.9 | 0.8 |
MRP, mV | -69.2 ± 0.9 | -72.9 ± 1.5 | -67.1 ± 2.3 | 0.06 |
Rin, MΩ | 297.2 ± 13.6 | 345.7 ± 14.9 | 342.2 ± 22.4 | 0.16 |
τ, ms | 31.9 ± 1.8 | 31.5 ± 2 | 30.7 ± 1.9 | 0.9 |
Cm, pF | 108.7 ± 9 | 89.1 ± 7.1 | 88.5 ± 6.3 | 0.16 |
Tg2576 and RSG-treated Tg2576 were compared with wild-type. Data are mean ± SE. P values were obtained with 1-way ANOVA and post hoc Dunnett test.
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|---|---|---|---|---|
Dentate gyrus granule cell | Dentate gyrus type 2 mature granule cell | first spike latency (ms) | 265.3 ± 17.4 | 265.3 (ms) | Data Table |
Dentate gyrus granule cell | Dentate gyrus type 2 mature granule cell | rheobase (pA) | 41.3 ± 5.5 | 41.3 (pA) | Data Table |
Dentate gyrus granule cell | Dentate gyrus type 2 mature granule cell | spike threshold (mV) | -45.2 ± 2.7 | -45.2 (mV) | Data Table |
Dentate gyrus granule cell | Dentate gyrus type 2 mature granule cell | resting membrane potential (mV) | -69.2 ± 0.9 | -69.2 (mV) | Data Table |
Dentate gyrus granule cell | Dentate gyrus type 2 mature granule cell | input resistance (MΩ) | 297.2 ± 13.6 | 297.2 (MΩ) | Data Table |
Dentate gyrus granule cell | Dentate gyrus type 2 mature granule cell | membrane time constant (ms) | 31.9 ± 1.8 | 31.9 (ms) | Data Table |
Dentate gyrus granule cell | Dentate gyrus type 2 mature granule cell | cell capacitance (pF) | 108.7 ± 9.0 | 108.7 (pF) | Data Table |