WMT1 | SW1 | Naı̈ve | WMT3 | SW3 | |
---|---|---|---|---|---|
1-spike sAHP amplitude, mV | −1.25 ± 0.11 | −1.16 ± 0.11 | −1.07 ± 0.1 | −1.37 ± 0.08 | −1.24 ± 0.08 |
n | 23 | 35 | 50 | 59 | 51 |
Latency of 1-spike sAHP peak, ms | 273 ± 20.3 | 283 ± 25.5 | 250 ± 23.8 | 261 ± 14.9 | 254 ± 16 |
I, nA to evoke 4 spikes | 0.32 ± 0.023-150 | 0.31 ± 0.023-160 | 0.38 ± 0.02 | 0.45 ± 0.033-152 | 0.45 ± 0.033-152 |
n | 64 | 65 | 62 | 64 | 63 |
Postburst sAHP amplitude, mV | −6 ± 0.3 | −6.3 ± 0.3 | −6.8 ± 0.4 | −7.7 ± 0.43-152 | −7.4 ± 0.33-151 |
Time to peak 4-spike sAHP, ms | 284 ± 8.9 | 287 ± 8.7 | 285 ± 9.8 | 278 ± 8.7 | 292 ± 8.3 |
Decay time to of sAHP peak, ms | 1,514 ± 51.7 | 1,561 ± 53.3 | 1,516 ± 63.1 | 1,427 ± 55.7 | 1,480 ± 63.5 |
Total time of interspike intervals in 4-spike burst, ms | 68.7 ± 1.9 | 65 ± 1.6 | 67.3 ± 1.1 | 66.3 ± 1.2 | 67.7 ± 1.3 |
Spike height, mV | 78.1 ± 0.7 | 77.6 ± 0.6 | 77.3 ± 0.6 | 81.6 ± 0.83-153 3-170 | 80.1 ± 0.63-160 3-152 |
Spike width, ms | 1.42 ± 0.2 | 1.36 ± 0.1 | 1.43 ± 0.02 | 1.43 ± 0.02 | 1.48 ± 0.02 |
Number of spikes per 800-ms | 5.5 ± 0.2 | 5.5 ± 0.2 | 5.7 ± 0.3 | 5.4 ± 0.2 | 5.5 ± 0.2 |
n | 60 | 63 | 62 | 62 | 62 |
ΔV m below 1-st spike threshold in 4-spike burst | 8.4 ± 0.3 | 8.2 ± 0.3 | 8.7 ± 0.3 | 8.8 ± 0.3 | 8.4 ± 0.3 |
Membrane potential, mV | −64.4 ± 0.3 | −64.2 ± 0.3 | −64.4 ± 0.3 | −64.8 ± 0.26 | −64.4 ± 0.28 |
Resting V m before electrode was withdrawn, mV | −61.7 ± 0.6 | −61.4 ± 0.6 | −61.3 ± 0.6 | −63.5 ± 0.7 | −62.7 ± 0.6 |
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There was no learning-specific modification of intrinsic membrane excitability following water-maze training in CA1 pyramidal cells. sAHP, slow after hyperpolarization.
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↵F3-150 P < 0.05,
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↵F3-160 P < 0.01,
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F3-165 P < 0.0001 significantly different from naı̈ve control;
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↵F3-151 P < 0.05,
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↵F3-152 P < 0.01,
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↵F3-170 P < 0.001 significantly different from the SW1 and WMT1 cells, Fisher's post hoc test;
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↵F3-153 P < 0.001 significantly different from the naive cells, Scheffe's post hoc test.