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Article: Motor neuron rescue in spinal muscular atrophy mice demonstrates that sensory-motor defects are a consequence, not a cause, of motor neuron dysfunction.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Gogliotti RG; Quinlan KA; Barlow CB; Heier CR; Heckman CJ; Didonato CJ
J. Neurosci., 2012

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Spinal cord ventral horn motor neuron alpha cell capacitance (pF) 224.0 ± 34.0 (12) 224.0 (pF) Data Table
Spinal cord ventral horn motor neuron alpha FI slope (Hz/nA) 37.0 ± 8.0 (12) 37.0 (Hz/nA) Data Table
Spinal cord ventral horn motor neuron alpha input resistance (MΩ) 62.0 ± 6.0 (12) 62.0 (MΩ) Data Table
Spinal cord ventral horn motor neuron alpha resting membrane potential (mV) -57.0 ± 1.0 (12) -57.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha spike half-width (ms) 1.29 ± 0.1 (12) 1.29 (ms) Data Table
Spinal cord ventral horn motor neuron alpha spike max rise slope (mV/ms) 97.0 ± 9.0 (12) 97.0 (mV/ms) Data Table
Spinal cord ventral horn motor neuron alpha spike peak (mV) 30.5 ± 2.0 (12) 30.5 (mV) Data Table
Spinal cord ventral horn motor neuron alpha spike threshold (mV) -33.9 ± 1.9 (12) -33.9 (mV) Data Table

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Metadata values

Experimental condition Value
Species Mice
ElectrodeType Patch-clamp
PrepType in vitro
Strain Mouse, Transgenic
AnimalAge 4.0 - 5.0
ExternalSolution 5.0
InternalSolution 5.0
JxnPotential Unreported
RecTemp 20.0 - 24.0
internal_0_Mg 5.0
internal_0_K 138.0
internal_0_GTP 0.3
internal_0_ATP 5.0
internal_0_HEPES 10.0
external_0_Mg 1.26
external_0_Na 136.0
external_0_K 4.19
external_0_Cl 119.13
external_0_Ca 2.52
external_0_glucose 11.1

Data table listing

Data Table Article Title Authors Journal Year Table needs expert? Ephys table mentions Curated by Times validated
1456 Motor neuron rescue in spinal muscular atrophy mice demonstrates that sensory-motor defects are a consequence, not a cause, of motor neuron dysfunction. Gogliotti RG; Quinlan KA; Barlow CB; Heier CR; Heckman CJ; Didonato CJ J. Neurosci. 2012 False 8 Shreejoy Tripathy, Brenna Li, Ryan Sefidpour, Athanasios Kritharis, Hannah Sangra, 5
1455 Motor neuron rescue in spinal muscular atrophy mice demonstrates that sensory-motor defects are a consequence, not a cause, of motor neuron dysfunction. Gogliotti RG; Quinlan KA; Barlow CB; Heier CR; Heckman CJ; Didonato CJ J. Neurosci. 2012 False 0 None