Table 1. Intrinsic excitability of hippocampal CA1 pyramidal cells at P14
Measurement | WT | Fmr1 KO2 | P valuec |
---|---|---|---|
Measurements were made by whole-cell recordings in WT (n = 12) and Fmr1 KO cells (n = 18).a Injected current required to evoke one spike (600 ms);b 600 ms current injection;c Student's unpaired t test; *mAHP, membrane afterhyperpolarization. | |||
Resting membrane potential (mV) | −65.6 ± 3.2 | 65.8 ± 2.9 | 0.82 |
Input resistance (MΩ) | 151 ± 63 | 155 ± 32 | 0.84 |
mAHP* amplitude (mV) | 6.3 ± 3.5 | 6.1 ± 3.2 | 0.93 |
Spike threshold (mV) | −49.0 ± 3.2 | −50.8 ± 3.1 | 0.13 |
Rheobase (Rh; pA)a | 70 ± 28 | 52 ± 28 | 0.1 |
Number of spikes at (Rh + 20 mV)b | 7.5 ± 4.5 | 7.5 ± 3.1 | 1 |