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Article: Characteristics and physiological role of hyperpolarization activated currents in mouse cold thermoreceptors.

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Orio P; Madrid R; de la Peña E; Parra A; Meseguer V; Bayliss DA; Belmonte C; Viana F
J. Physiol. (Lond.), 2009


Table 2. Effect of 20 μm ZD7288 on membrane parameters of CS neurons

Parameter Control ZD7288 (20 μm) n P
Input resistance was calculated from the peak voltage response to a hyperpolarizing current pulse. Rheobase current was measured by injection of a 1 nA s−1 current ramp. Action potential (AP) properties were measured after brief (5 ms) current injections. P is the result of a paired t test.
Input resistance (MΩ) 424 ± 79 657 ± 102 15  0.0001
Resting potential (mV) −60.0 ± 1.7  −64.9 ± 2.1    15  0.0009
Rheobase current (pA pF−1) 10.8 ± 5.3 12.8 ± 6.6  6 0.6   
AP half-width (ms)  0.82 ± 0.17 0.88 ± 0.06 5 0.003 
AP peak amplitude (mV)  90 ± 6.3  81 ± 5.1 5 0.01  

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
DRG temperature cell Trigeminal cold sensitive ganglia input resistance (MΩ) 424.0 ± 79.0 (15) 424.0 (MΩ) Data Table
DRG temperature cell Trigeminal cold sensitive ganglia resting membrane potential (mV) -60.0 ± 1.7 (15) -60.0 (mV) Data Table
DRG temperature cell Trigeminal cold sensitive ganglia rheobase 10.8 ± 5.3 (6) 10.8 (pA) Data Table
DRG temperature cell Trigeminal cold sensitive ganglia spike half-width (ms) 0.82 ± 0.17 (5) 0.82 (ms) Data Table
DRG temperature cell Trigeminal cold sensitive ganglia spike amplitude (mV) 90.0 ± 6.3 (5) 90.0 (mV) Data Table