Parameter | Control | ZD7288 (20 μm) | n | P |
---|---|---|---|---|
Input resistance was calculated from the peak voltage response to a hyperpolarizing current pulse. Rheobase current was measured by injection of a 1 nA s−1 current ramp. Action potential (AP) properties were measured after brief (5 ms) current injections. P is the result of a paired t test. | ||||
Input resistance (MΩ) | 424 ± 79 | 657 ± 102 | 15 | 0.0001 |
Resting potential (mV) | −60.0 ± 1.7 | −64.9 ± 2.1 | 15 | 0.0009 |
Rheobase current (pA pF−1) | 10.8 ± 5.3 | 12.8 ± 6.6 | 6 | 0.6 |
AP half-width (ms) | 0.82 ± 0.17 | 0.88 ± 0.06 | 5 | 0.003 |
AP peak amplitude (mV) | 90 ± 6.3 | 81 ± 5.1 | 5 | 0.01 |
Article: Characteristics and physiological role of hyperpolarization activated currents in mouse cold thermoreceptors.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Orio P; Madrid R; de la Peña E; Parra A; Meseguer V; Bayliss DA; Belmonte C; Viana F J. Physiol. (Lond.), 2009
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|---|---|---|---|---|
DRG temperature cell | Trigeminal cold sensitive ganglia | input resistance (MΩ) | 424.0 ± 79.0 (15) | 424.0 (MΩ) | Data Table |
DRG temperature cell | Trigeminal cold sensitive ganglia | resting membrane potential (mV) | -60.0 ± 1.7 (15) | -60.0 (mV) | Data Table |
DRG temperature cell | Trigeminal cold sensitive ganglia | rheobase | 10.8 ± 5.3 (6) | 10.8 (pA) | Data Table |
DRG temperature cell | Trigeminal cold sensitive ganglia | spike half-width (ms) | 0.82 ± 0.17 (5) | 0.82 (ms) | Data Table |
DRG temperature cell | Trigeminal cold sensitive ganglia | spike amplitude (mV) | 90.0 ± 6.3 (5) | 90.0 (mV) | Data Table |