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Article: Effect of prolonged riluzole exposure on cultured motoneurons in a mouse model of ALS.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Schuster JE; Fu R; Siddique T; Heckman CJ
J. Neurophysiol., 2012


Table 1.

Passive and firing properties

Measure Significance Direction wt 0 μΜ SOD1 0 μΜ wt 2 μΜ SOD1 2 μΜ
Cell size N = 57 N = 32 N = 59 N = 40
    Diameter, μm ns 25.7 ± 4.9 25.2 ± 3.5 26.0 ± 4.3 26.6 ± 4.4
Passive properties N = 57 N = 32 N = 59 N = 40
    RMP, mV Drug* 0 > 2 −50.5 ± 6.4 −49.2 ± 5.5 −52.7 ± 7.0 −52.0 ± 7.4
    Capacitance, pF Ns 30.4 ± 17.5 34.0 ± 16.6 33.5 ± 14.3 31.2 ± 10.6
N = 47 N = 25 N = 52 N = 30
    Leak conductance, nS Genotype* WT > SOD1 2.8 ± 1.3 2.6 ± 1.3 2.9 ± 1.6 2.1 ± 1.0
AP and FI data N = 57 N = 31 N = 59 N = 38
    Height (>0 mV) Ns 32.4 ± 6.8 32.8 ± 6.7 32.9 ± 8.0 32.2 ± 7.0
    Voltage threshold, mV Ns −31.7 ± 3.8 −32.7 ± 5.1 −33.4 ± 4.5 −32.1 ± 3.6
N = 56 N = 25 N = 56 N = 37
    Current threshold, pA Genotype* WT > SOD1 26.8 ± 41.6 5.4 ± 32.0 28.2 ± 54.5 19.3 ± 34.9
N = 56 N = 30 N = 54 N = 35
    ΔI, pA Ns −29.7 ± 18.3 −24.3 ± 13.7 −31.4 ± 21.9 −27.7 ± 13.9
    Ascending gain, Hz/pA Ns 0.240 ± 0.09 0.251 ± 0.09 0.233 ± 0.12 0.227 ± 0.08
N = 50 N = 28 N = 51 N = 31
    Descending gain, Hz/pA Ns 0.382 ± 0.15 0.366 ± 0.15 0.346 ± 0.15 0.370 ± 0.13
N = 19 N = 20 N = 8 N = 7
    Spont. activity, AP/min 71.5 ± 152 176.6 ± 197 139.5 ± 193 71.2 ± 152

  • Means ± SD for each of the 4 individual groups are presented separately (genotype:drug): wild type (wt) control (0 μM), superoxide dismutase 1 mutant (SOD1) control (0 μM), wt riluzole (2 μM), and SOD1 riluzole (2 μM). The number of cells per group (N) is above each series of measurements. RMP, resting membrane potential; AP, action potential; FI, frequency-current; ΔI, difference between current at AP recruitment and derecruitment; Spont., spontaneous. Significant differences for drug, genotype, and interactions are listed in a separate column. Significance: not significant (ns),

  • ↵* 0.05 ≥ P > 0.01. The direction of each significant difference is listed in a separate column. The direction is based on actual, not absolute, values.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Spinal Cord Motor Neuron FI slope (Hz/pA) 0.24 ± 0.09 (56) 240.0 (Hz/nA) Data Table
Other Spinal Cord Motor Neuron cell diameter (μm) 25.7 ± 4.9 (57) 25.7 (um) Data Table
Other Spinal Cord Motor Neuron firing frequency 71.5 ± 152.0 (19) 71.5 (Hz) Data Table
Other Spinal Cord Motor Neuron resting membrane potential (mV) -50.5 ± 6.4 (57) -50.5 (mV) Data Table
Other Spinal Cord Motor Neuron cell capacitance (pF) 30.4 ± 17.5 (57) 30.4 (pF) Data Table
Other Spinal Cord Motor Neuron spike peak 32.4 ± 6.8 (57) 32.4 (mV) Data Table
Other Spinal Cord Motor Neuron spike threshold (mV) -31.7 ± 3.8 (57) -31.7 (mV) Data Table
Other Spinal Cord Motor Neuron rheobase (pA) 26.8 ± 41.6 (56) 26.8 (pA) Data Table