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Article: Characterization of neuronal migration disorders in neocortical structures. II. Intracellular in vitro recordings.

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Luhmann HJ; Karpuk N; Qü M; Zilles K
J. Neurophysiol., 1998


Table 1.

Intrinsic membrane properties in normal and microgyric rat cortex

Parameter Control NMD
Resting membrane potential, mV −83 ± 1 (51) −80.4 ± 1.7 (49)
Input resistance, MΩ 39.9 ± 2.1 (50) 41.6 ± 1.9 (49)
Spike amplitude, mV 109 ± 1.6 (51)  100.2 ± 2 (49)1-165
Maximum rate of spike rise, V/s 276 ± 8.8 (51)  208.2 ± 10 (47)1-165
Maximum rate of spike fall, V/s 79.8 ± 2.5 (51) 75.2 ± 3.2 (47)
dV/dt ratio 3.51 ± 0.09 (51) 2.93 ± 0.15 (47)1-165
Primary f-I slope, Hz/nA  156 ± 10.2 (30) 93.5 ± 11 (30)1-165
  • Passive and active intrinsic membrane properties in upper layer regular spiking cells in parietal cortical slices from adult sham-operated rats (control) and age-matched animals with focal neuronal migration disorder (NMD). All data are expressed as means ± SE and number of cells are given in parentheses. Statistically significant differences are indicated by

  • * P < 0.05,

  • F1-160 P < 0.01, and

  • F1-165 P < 0.001.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 2-3 Dysplastic Cortex Regular Spiking Neuron spike max rise slope (V/s) 276.0 ± 8.8 (51) 276.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 2-3 Dysplastic Cortex Regular Spiking Neuron spike max decay slope (V/s) 79.8 ± 2.5 (51) 79.8 (mV/ms) Data Table
Neocortex pyramidal cell layer 2-3 Dysplastic Cortex Regular Spiking Neuron resting membrane potential (mV) -83.0 ± 1.0 (51) -83.0 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Dysplastic Cortex Regular Spiking Neuron FI slope (Hz/nA) 156.0 ± 10.2 (30) 156.0 (Hz/nA) Data Table
Neocortex pyramidal cell layer 2-3 Dysplastic Cortex Regular Spiking Neuron input resistance (MΩ) 39.9 ± 2.1 (50) 39.9 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Dysplastic Cortex Regular Spiking Neuron spike amplitude (mV) 109.0 ± 1.6 (51) 109.0 (mV) Data Table