Parameter | Control | NMD |
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Resting membrane potential, mV | −83 ± 1 (51) | −80.4 ± 1.7 (49) |
Input resistance, MΩ | 39.9 ± 2.1 (50) | 41.6 ± 1.9 (49) |
Spike amplitude, mV | 109 ± 1.6 (51) | 100.2 ± 2 (49)1-165 |
Maximum rate of spike rise, V/s | 276 ± 8.8 (51) | 208.2 ± 10 (47)1-165 |
Maximum rate of spike fall, V/s | 79.8 ± 2.5 (51) | 75.2 ± 3.2 (47) |
dV/dt ratio | 3.51 ± 0.09 (51) | 2.93 ± 0.15 (47)1-165 |
Primary f-I slope, Hz/nA | 156 ± 10.2 (30) | 93.5 ± 11 (30)1-165 |
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Passive and active intrinsic membrane properties in upper layer regular spiking cells in parietal cortical slices from adult sham-operated rats (control) and age-matched animals with focal neuronal migration disorder (NMD). All data are expressed as means ± SE and number of cells are given in parentheses. Statistically significant differences are indicated by
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* P < 0.05,
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F1-160 P < 0.01, and
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↵F1-165 P < 0.001.